8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one

Modify Date: 2026-08-24 07:56:30

8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one structure	Common Name	8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one
	CAS Number	1810721-14-2	Molecular Weight	422.9
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₃ClN₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula	C₂₂H₂₃ClN₆O
Molecular Weight	422.9
InChIKey	ZLJBWVWHTDCWFO-UHFFFAOYSA-N
SMILES	Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NCNC4=O)cc2)cn1

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Permeability across apical to basolateral side in human Caco2 cells after 2 hrs by LC...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803423

Name: Intrinsic clearance in mouse microsomes preincubated for 5 mins followed by addition ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803439

Name: Intrinsic clearance in rat microsomes preincubated for 5 mins followed by addition of...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803438

Name: Efflux ratio in human Caco2 cells after 2 hrs by LC-MS/MS analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803422

Name: Binding affinity to CDK8/CDK19 in human 7dF3 cells preincubated for 2 hrs followed by...
Source: ChEMBL
Target: Cyclin-dependent kinase 19
External Id: CHEMBL3803421

Name: Binding affinity to human CDK19 (1 to 502 amino acid residues)/Cyclin C (1 to 283 ami...
Source: ChEMBL
Target: Cyclin-C
External Id: CHEMBL3803437

Name: Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lant...
Source: ChEMBL
Target: Cyclin-dependent kinase 8
External Id: CHEMBL3803436

Name: Thermodynamic solubility of compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803442

Name: Kinetic solubility of compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803441

Name: Intrinsic clearance in human microsomes preincubated for 5 mins followed by addition ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3803440

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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: InChIKey of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is ZLJBWVWHTDCWFO-UHFFFAOYSA-N.

Q: What is the molecular formula of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: Molecular formula of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is C22H23ClN6O.

Q: What is the Chinese name of 1810721-14-2?

A: Chinese name of 1810721-14-2 is 1810721-14-2.

Q: What is the CAS number of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: CAS number of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is 1810721-14-2.

Q: What is the English name of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: The English name of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one.

Q: What is the molecular weight of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: Molecular weight of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is 422.9.

Q: What is the SMILES notation of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one?

A: SMILES notation of 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one is Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NCNC4=O)cc2)cn1.

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8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.