V-9302

• 常用名: V-9302
• 英文名: V-9302
• CAS号: 1855871-76-9
• 分子量: 538.68
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₃₈N₂O₄
• 熔点: N/A
• 闪点: N/A

V-9302用途

V-9302 是一种跨膜谷氨酰胺通量的竞争性拮抗剂,能有效选择性的靶向氨基酸转运体 ASCT2,其 IC50 值为 9.6 μM。V-9302 显示抗肿瘤活性。

V-9302名称

• 中文名: V-9302
• 英文名: V-9302

V-9302生物活性

• 描述: V-9302 是一种跨膜谷氨酰胺通量的竞争性拮抗剂,能有效选择性的靶向氨基酸转运体 ASCT2,其 IC50 值为 9.6 μM。V-9302 显示抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 9.6 μM (ASCT2)[1]

• 参考文献:

  [1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.

V-9302物理化学性质

• 分子式: C₃₄H₃₈N₂O₄
• 分子量: 538.68
• 储存条件: 2-8℃

V-9302靶点实验

查看更多实验

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540542

实验名称：AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540543

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540544

实验名称：Half life in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540545

实验名称：Inhibition of ASCT2 in human A549 cells assessed as reduction in [13C]-Gln uptake at ... 来源：ChEMBL 靶标：Neutral amino acid transporter B(0) External Id：CHEMBL5540514

实验名称：Apparent volume of distribution with respect to the bioavailability in Sprague-Dawley... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540546

实验名称：Apparent clearance in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540547

实验名称：Inhibition of ASCT2 in HEK293 cells assessed as reduction in [13C]-Gln uptake at 50 u... 来源：ChEMBL 靶标：Neutral amino acid transporter B(0) External Id：CHEMBL5540515

实验名称：Antiproliferative activity against human A549 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5540516

实验名称：MRT (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, ip incubated for 24 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540548

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