Methylproamine

更新时间：2025-08-25 18:34:24

Methylproamine结构式	常用名	Methylproamine	英文名	Methylproamine
	CAS号	188247-01-0	分子量	465.59300
	密度	N/A	沸点	N/A
	分子式	C₂₈H₃₁N₇	熔点	N/A
	MSDS	N/A	闪点	N/A

Methylproamine用途

Methylproamine是DNA结合的辐射保护剂,能修复辐射诱导的短暂活性氧。

中文名	Methylproamine
英文名	N,N,3-trimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
英文别名	更多

描述	Methylproamine是DNA结合的辐射保护剂,能修复辐射诱导的短暂活性氧。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 癌症染料试剂
参考文献	[1]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [2]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. [3]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70.

描述

Methylproamine是DNA结合的辐射保护剂,能修复辐射诱导的短暂活性氧。

相关类别

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

染料试剂

参考文献

[1]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83.

[2]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52.

[3]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70.

分子式	C₂₈H₃₁N₇
分子量	465.59300
精确质量	465.26400
PSA	67.08000
LogP	4.90230
InChIKey	ADKLMOJIJGHCCD-UHFFFAOYSA-N
SMILES	Cc1cc(N(C)C)ccc1-c1nc2ccc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)cc2[nH]1
储存条件	-20℃

4-二甲氨基邻甲苯醛

1199-59-3

1,2-Benzenediam...

23491-49-8

~81%

Methylproamine

188247-01-0

文献：Peter MacCallum Cancer Institute Patent: EP2044938 A2, 2009 ; Location in patent: Page/Page column 21 ;

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Confirmatory Screen for Target Class Profiling of Small Molecule Inhibitors of Methyl...
来源：NCGC
External Id：MTASE-f-cherrypicks

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans...
来源：NCGC
External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
来源：NCGC
External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
来源：NCGC
靶标：N/A
External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
来源：NCGC
External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
来源：NCGC
External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i...
来源：NCGC
External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i...
来源：NCGC
External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ...
来源：NCGC
External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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Methylproamine

CS-1306