2’-β-C-Ethynylcytidine

• 常用名: 2’-β-C-Ethynylcytidine
• 英文名: 2’-β-C-Ethynylcytidine
• CAS号: 188413-99-2
• 分子量: 267.24
• 密度: 1.6±0.1 g/cm3
• 沸点: 536.4±60.0 °C at 760 mmHg
• 分子式: C₁₁H₁₃N₃O₅
• 熔点: N/A
• 闪点: 278.2±32.9 °C

2’-β-C-Ethynylcytidine用途

2'-β-丙炔基胞苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

2’-β-C-Ethynylcytidine名称

• 英文名: 2'-C-Ethynylcytidine

2’-β-C-Ethynylcytidine生物活性

• 描述: 2'-β-丙炔基胞苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

2’-β-C-Ethynylcytidine物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 536.4±60.0 °C at 760 mmHg
• 分子式: C₁₁H₁₃N₃O₅
• 分子量: 267.24
• 闪点: 278.2±32.9 °C
• 精确质量: 267.085510
• LogP: 0.10
• InChIKey: LMPQMWCSENOFHW-PNHWDRBUSA-N
• SMILES: C#CC1(O)C(O)C(CO)OC1n1ccc(N)nc1=O
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.677

2’-β-C-Ethynylcytidine靶点实验

查看更多实验

实验名称：Antiviral activity against WNV infected in BHK-21 cells assessed as inhibition of vir... 来源：ChEMBL 靶标：West Nile virus External Id：CHEMBL3738573

实验名称：Antiviral activity against Human coxsackievirus B2 infected African green monkey Vero... 来源：ChEMBL 靶标：Coxsackievirus B2 External Id：CHEMBL3054843

实验名称：Cytotoxicity against human A549 cells assessed as intracellular ATP level by Celltite... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1637304

实验名称：Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells ass... 来源：ChEMBL 靶标：dengue virus type 2 External Id：CHEMBL1637305

实验名称：Antiviral activity against Vaccinia virus 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL3738730

实验名称：Antiviral activity against VSV 来源：ChEMBL 靶标：Vesicular stomatitis virus External Id：CHEMBL3738729

实验名称：Antiviral activity against HSV1 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3738728

实验名称：Antiviral activity against human CVB5 infected in african green monkey Vero76 cells a... 来源：ChEMBL 靶标：Coxsackievirus B5 External Id：CHEMBL3738055

实验名称：Antiviral activity against Reo-1 virus infected in BHK-21 cells assessed as inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3738054

实验名称：Antiviral activity against YFV infected in BHK-21 cells assessed as inhibition of vir... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL3738053

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2’-β-C-Ethynylcytidine英文别名

• 2'-C-Ethynylcytidine