2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑

更新时间：2025-08-25 11:26:36

用途

KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。

中文名	2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
英文名	2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole
英文别名	更多

描述	KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体研究领域 >> 代谢疾病
参考文献	[1]. Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75. [2]. Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2 [3]. Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96. [4]. Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102. [5]. Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.

描述

KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体

研究领域 >> 代谢疾病

参考文献

密度	1.2±0.1 g/cm3
沸点	428.1±34.0 °C at 760 mmHg
熔点	137-139ºC
分子式	C₁₃H₁₄N₂O
分子量	214.263
闪点	154.4±15.9 °C
精确质量	214.110611
PSA	37.91000
LogP	2.10
InChIKey	JCWVNNMJXQJVNC-UHFFFAOYSA-N
SMILES	CCC1(c2ncc[nH]2)Cc2ccccc2O1
外观性状	白色固体
蒸汽压	0.0±1.0 mmHg at 25°C
折射率	1.595
储存条件	Store at RT

cs-1007

1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-

hms3267m22

ku14r

2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole