2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑

• 常用名: 2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
• 英文名: KU14R
• CAS号: 189224-48-4
• 分子量: 214.263
• 密度: 1.2±0.1 g/cm3
• 沸点: 428.1±34.0 °C at 760 mmHg
• 分子式: C₁₃H₁₄N₂O
• 熔点: 137-139ºC
• 闪点: 154.4±15.9 °C

用途

KU14R是胰岛素受体拮抗剂，能选择性阻断由咪唑啉引起的胰岛素分泌。

2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑名称

• 中文名: 2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
• 英文名: 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole

2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑生物活性

• 描述: KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75.

  [2]. Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2

  [3]. Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96.

  [4]. Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102.

  [5]. Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.

2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 428.1±34.0 °C at 760 mmHg
• 熔点: 137-139ºC
• 分子式: C₁₃H₁₄N₂O
• 分子量: 214.263
• 闪点: 154.4±15.9 °C
• 精确质量: 214.110611
• PSA: 37.91000
• LogP: 2.10
• InChIKey: JCWVNNMJXQJVNC-UHFFFAOYSA-N
• SMILES: CCC1(c2ncc[nH]2)Cc2ccccc2O1
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.595
• 储存条件: Store at RT

2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑靶点实验

查看更多实验

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

共12条，当前第1页，共2页

1

2

2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑英文别名

• cs-1007
• hms3267m22
• ku14r
• 2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole