Ro 10-5824 dihydrochloride

• 常用名: Ro 10-5824 dihydrochloride
• 英文名: Ro 10-5824 dihydrochloride
• CAS号: 189744-46-5
• 分子量: 353.28900
• 密度: N/A
• 沸点: 506.2ºC at 760 mmHg
• 分子式: C₁₇H₂₂Cl₂N₄
• 熔点: N/A
• 闪点: 260ºC

Ro 10-5824 dihydrochloride用途

RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders. The identification of effective medications for the management of cocaine use disorders remains an unmet public health challenge. In view of the prominent role of dopaminergic mechanisms in cocaine's abuse-related effects, research has focused on the development of subtype-selective dopamine D1-4 receptor antagonists.

Ro 10-5824 dihydrochloride名称

• 英文名: 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-2-methyl-pyrimidin-4-ylamine

Ro 10-5824 dihydrochloride物理化学性质

• 沸点: 506.2ºC at 760 mmHg
• 分子式: C₁₇H₂₂Cl₂N₄
• 分子量: 353.28900
• 闪点: 260ºC
• 精确质量: 352.12200
• PSA: 55.04000
• LogP: 4.77960
• InChIKey: KABDATZAOUSYES-UHFFFAOYSA-N
• SMILES: Cc1ncc(CN2CC=C(c3ccccc3)CC2)c(N)n1
• 蒸汽压: 1.28E-10mmHg at 25°C

Ro 10-5824 dihydrochloride靶点实验

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实验名称：Displacement of 3H-N-Methylspiperone from DRD4 F2.61V / L3.28F mutant in human HEK293... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5721348

实验名称：Bios factor, ratio of agonist activity at DRD4-mediated arrestin signaling to agonist... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5721366

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Agonist activity at human D4R at 10 uM relative to control 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5235441

实验名称：Binding affinity to human D2R assessed as inhibition constant 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5235409

实验名称：Displacement of 3H-N-Methylspiperone from DRD4 in human HEK293T cells membrane assess... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5721345

实验名称：Binding affinity to human D3R assessed as inhibition constant 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL5235421

实验名称：Displacement of [3H]-spiperone from human D4 receptor expressed in CHO cells assessed... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5235422

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Ro 10-5824 dihydrochloride英文别名

• Ro 10-5824 dihydrochloride
• RO 10-5824