Ro 10-5824 dihydrochloride

• 常用名: Ro 10-5824 dihydrochloride
• 英文名: Ro 10-5824 dihydrochloride
• CAS号: 189744-46-5
• 分子量: 353.28900
• 密度: N/A
• 沸点: 506.2ºC at 760 mmHg
• 分子式: C₁₇H₂₂Cl₂N₄
• 熔点: N/A
• 闪点: 260ºC

Ro 10-5824 dihydrochloride用途

RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders. The identification of effective medications for the management of cocaine use disorders remains an unmet public health challenge. In view of the prominent role of dopaminergic mechanisms in cocaine's abuse-related effects, research has focused on the development of subtype-selective dopamine D1-4 receptor antagonists.

Ro 10-5824 dihydrochloride名称

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

• 英文名: 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-2-methyl-pyrimidin-4-ylamine

Ro 10-5824 dihydrochloride物理化学性质

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

• 沸点: 506.2ºC at 760 mmHg
• 分子式: C₁₇H₂₂Cl₂N₄
• 分子量: 353.28900
• 闪点: 260ºC
• 精确质量: 352.12200
• PSA: 55.04000
• LogP: 4.77960
• InChIKey: KABDATZAOUSYES-UHFFFAOYSA-N
• SMILES: Cc1ncc(CN2CC=C(c3ccccc3)CC2)c(N)n1
• 蒸汽压: 1.28E-10mmHg at 25°C

Ro 10-5824 dihydrochloride靶点实验

查看更多实验

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Displacement of 3H-N-Methylspiperone from DRD4 F2.61V / L3.28F mutant in human HEK293... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5721348

实验名称：Bios factor, ratio of agonist activity at DRD4-mediated arrestin signaling to agonist... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5721366

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Agonist activity at human D4R at 10 uM relative to control 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5235441

实验名称：Binding affinity to human D2R assessed as inhibition constant 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5235409

实验名称：Displacement of 3H-N-Methylspiperone from DRD4 in human HEK293T cells membrane assess... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5721345

实验名称：Binding affinity to human D3R assessed as inhibition constant 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL5235421

实验名称：Displacement of [3H]-spiperone from human D4 receptor expressed in CHO cells assessed... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5235422

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Ro 10-5824 dihydrochloride英文别名

本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

• Ro 10-5824 dihydrochloride
• RO 10-5824

Ro 10-5824 dihydrochloride常见问题

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 189744-46-5的英文名称是什么？

A: 189744-46-5英文名称为5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-2-methyl-pyrimidin-4-ylamine。

Q: 189744-46-5的分子式是什么？

A: 189744-46-5分子式为C17H22Cl2N4。

Q: 189744-46-5的极性表面积PSA是多少？

A: 189744-46-5极性表面积PSA为55.04000。

Q: 189744-46-5的中文名称是什么？

A: 189744-46-5的中文名称为189744-46-5。

Q: 189744-46-5的分子量是多少？

A: 189744-46-5分子量为353.28900。

Q: 189744-46-5的CAS号是多少？

A: 189744-46-5CAS号为189744-46-5。

Q: 189744-46-5有什么用途？

A: 189744-46-5主要用途：RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders. The identification of effective medications for the management of cocaine use disorders remains an unmet public health challenge. In view of the prominent role of dopaminergic mechanisms in cocaine's abuse-related effects, research has focused on the development of subtype-selective dopamine D1-4 receptor antagonists.

Q: 189744-46-5的沸点是多少？

A: 189744-46-5沸点为506.2ºC at 760 mmHg。

Q: 189744-46-5的LogP（油水分配系数）是多少？

A: 189744-46-5LogP（油水分配系数）为4.77960。

Q: 189744-46-5有哪些英文别名？

A: 189744-46-5英文别名有：Ro 10-5824 dihydrochloride、 RO 10-5824。

Ro 10-5824 dihydrochloride生产厂家

本表列出该化合物相关生产厂商、供应商信息，包含厂家名称、产品供应相关参考信息。

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