189744-46-5

• 常用中文名：Ro 10-5824 dihydrochloride
• 常用英文名：Ro 10-5824 dihydrochloride
• CAS号：189744-46-5
• 分子式：C₁₇H₂₂Cl₂N₄
• 分子量：353.28900
• 发布时间：2016-10-07 10:15:55
• 更新时间：2026-10-28 18:30:13
• RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders. The identification of effective medications for the management of cocaine use disorders remains an unmet public health challenge. In view of the prominent role of dopaminergic mechanisms in cocaine's abuse-related effects, research has focused on the development of subtype-selective dopamine D1-4 receptor antagonists.

名称

• 英文名: 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-2-methyl-pyrimidin-4-ylamine
• 英文别名: Ro 4 dihydrochloride; RO 4; 4-Pyrimidinamine, 5-[(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl; RO 10-5824; 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE; 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine

物化性质

• 沸点: 506.2ºC at 760 mmHg
• 分子式: C₁₇H₂₂Cl₂N₄
• 分子量: 353.28900
• 闪点: 260ºC
• 精确质量: 352.12200
• PSA: 55.04000
• LogP: 4.77960
• 蒸汽压: 1.28E-10mmHg at 25°C

合成路线

43064-12-6 70476-08-3 ~% 189744-46-5

文献：Hoffmann-La Roche Inc. Patent: US5688798 A1, 1997 ;

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