Ezetimibe phenoxy glucuronide

• 常用名: Ezetimibe phenoxy glucuronide
• 英文名: Ezetimibe phenoxy glucuronide
• CAS号: 190448-57-8
• 分子量: 585.54900
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₂₉F₂NO₉
• 熔点: 140-150ºC
• 闪点: N/A

Ezetimibe phenoxy glucuronide用途

Ezetimibe phenoxy glucuronide 是 Ezetimibe 的活性代谢物,具有抗高脂蛋白血症效果。Ezetimibe 是有效的胆固醇吸收抑制剂。

Ezetimibe phenoxy glucuronide名称

• 中文名: 依泽替米贝β-D-葡萄糖醛酸
• 英文名: (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid

Ezetimibe phenoxy glucuronide生物活性

• 描述: Ezetimibe phenoxy glucuronide 是 Ezetimibe 的活性代谢物,具有抗高脂蛋白血症效果。Ezetimibe 是有效的胆固醇吸收抑制剂。
• 相关类别:
  研究领域 >> 代谢疾病
• 体外研究: 经口给药后,Ezetimibe被小肠吸收,超过80%的Ezetimibe代谢为Ezetimibe葡萄糖醛酸苷[1]。
• 参考文献:

  [1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.

  [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

Ezetimibe phenoxy glucuronide物理化学性质

• 熔点: 140-150ºC
• 分子式: C₃₀H₂₉F₂NO₉
• 分子量: 585.54900
• 精确质量: 585.18100
• PSA: 156.99000
• LogP: 2.51870
• InChIKey: UOFYCFMTERCNEW-ADEYADIWSA-N
• SMILES: O=C(O)C1OC(Oc2ccc(C3C(CCC(O)c4ccc(F)cc4)C(=O)N3c3ccc(F)cc3)cc2)C(O)C(O)C1O
• 外观性状: 固体
• 折射率: 1.65
• 储存条件: 2-8°C，密封，干燥

Ezetimibe phenoxy glucuronide靶点实验

查看更多实验

实验名称：Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush bor... 来源：ChEMBL 靶标：NPC1-like intracellular cholesterol transporter 1 External Id：CHEMBL932102

实验名称：Drug level in methionine and choline deficient fed Sprague-Dawley rat bile treated wi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3529502

实验名称：Dose required to inhibit cholesterol absorption in cholesterol fed hamster model 来源：ChEMBL 靶标：Cricetinae gen. sp. External Id：CHEMBL694328

实验名称：Compound was tested for percent reduction of liver cholesterol esters absorption in c... 来源：ChEMBL 靶标：Cricetinae gen. sp. External Id：CHEMBL693044

实验名称：Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydro... 来源：ChEMBL 靶标：Niemann-Pick C1-like 1 protein External Id：CHEMBL970545

实验名称：Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydro... 来源：ChEMBL 靶标：Niemann-Pick C1-like 1 protein External Id：CHEMBL970544

实验名称：Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970546

实验名称：Drug level in methionine and choline deficient fed Sprague-Dawley rat bile treated wi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3537648

实验名称：Metabolic stability assessed as half life in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL931186

实验名称：Drug level in methionine and choline deficient fed Sprague-Dawley rat urine treated w... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3528195

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Ezetimibe phenoxy glucuronide英文别名

• Ezetimibe Phenoxy Glucuronide
• ezetimibe-glucuronide
• EZM-G