Ezetimibe phenoxy glucuronide

Modify Date: 2024-01-02 12:14:48

Ezetimibe phenoxy glucuronide Structure
Ezetimibe phenoxy glucuronide structure
Common Name Ezetimibe phenoxy glucuronide
CAS Number 190448-57-8 Molecular Weight 585.54900
Density N/A Boiling Point N/A
Molecular Formula C30H29F2NO9 Melting Point 140-150ºC
MSDS N/A Flash Point N/A

 Use of Ezetimibe phenoxy glucuronide


Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

 Names

Name (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonym More Synonyms

 Ezetimibe phenoxy glucuronide Biological Activity

Description Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
Related Catalog
In Vitro After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].
References

[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.

[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

 Chemical & Physical Properties

Melting Point 140-150ºC
Molecular Formula C30H29F2NO9
Molecular Weight 585.54900
Exact Mass 585.18100
PSA 156.99000
LogP 2.51870
Index of Refraction 1.65

 Synonyms

Ezetimibe Phenoxy Glucuronide
ezetimibe-glucuronide
EZM-G