K-7174二盐酸盐

• 常用名: K-7174二盐酸盐
• 英文名: K-7174 (dihydrochloride)
• CAS号: 191089-60-8
• 分子量: 641.67
• 密度: 1.1±0.1 g/cm3
• 沸点: 689.9±55.0 °C at 760 mmHg
• 分子式: C₃₃H₅₀Cl₂N₂O₆
• 熔点: N/A
• 闪点: 171.2±28.7 °C

K-7174二盐酸盐用途

K-7174二盐酸盐是细胞粘附抑制剂,能抑制VCAM-1的表达量。

K-7174二盐酸盐名称

• 中文名: K-7174二盐酸盐
• 英文名: 1,4-Bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-1,4-diazepane

K-7174二盐酸盐生物活性

• 描述: K-7174二盐酸盐是细胞粘附抑制剂,能抑制VCAM-1的表达量。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.

  [2]. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4.

  [3]. Shimada T, et al. Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress. Biochem Biophys Res Commun. 2007 Nov 16;363(2):355-60.

  [4]. Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.

K-7174二盐酸盐物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 689.9±55.0 °C at 760 mmHg
• 分子式: C₃₃H₅₀Cl₂N₂O₆
• 分子量: 641.67
• 闪点: 171.2±28.7 °C
• LogP: 5.61
• InChIKey: JKAQFPBRMVEHBD-CHBZAFCASA-N
• SMILES: COc1cc(C=CCCCN2CCCN(CCCC=Cc3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC.Cl.Cl
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.552
• 储存条件: 2-8℃

K-7174二盐酸盐英文别名

• 1,4-Bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-1,4-diazepane
• K-7174 (dihydrochloride)