通关藤苷G

• 常用名: 通关藤苷G
• 英文名: Tenacissoside G
• CAS号: 191729-43-8
• 分子量: 792.949
• 密度: 1.3±0.1 g/cm3
• 沸点: 821.8±65.0 °C at 760 mmHg
• 分子式: C₄₂H₆₄O₁₄
• 熔点: N/A
• 闪点: 238.4±27.8 °C

通关藤苷G用途

Tenacissoside G 是一种来自 Marsdenia tenacissima 茎部的 C21 甾体。Tenacissoside G 逆转 P-糖蛋白 (Pgp) 过度表达的多药耐药癌细胞的多药耐药。

通关藤苷G名称

• 中文名: 通关藤苷G
• 英文名: (3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl (2E)-2-methyl-2-butenoate
• 中文别名: 通关藤皂苷G

通关藤苷G生物活性

• 描述: Tenacissoside G 是一种来自 Marsdenia tenacissima 茎部的 C21 甾体。Tenacissoside G 逆转 P-糖蛋白 (Pgp) 过度表达的多药耐药癌细胞的多药耐药。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Lei YS, et al. [C21 steroids from the stems of Marsdenia tenacissima]. Yao Xue Xue Bao. 2008 May;43(5):509-12.

  [2]. Hu YJ, et al. Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells. J Nat Prod. 2008 Jun;71(6):1049-51.

通关藤苷G物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 821.8±65.0 °C at 760 mmHg
• 分子式: C₄₂H₆₄O₁₄
• 分子量: 792.949
• 闪点: 238.4±27.8 °C
• 精确质量: 792.429626
• PSA: 178.04000
• LogP: 5.01
• InChIKey: OHDJGUWKOIBIKY-PVVGWVMJSA-N
• SMILES: CC=C(C)C(=O)OC1C2C3(C)CCC(OC4CC(OC)C(OC5OC(C)C(O)C(OC)C5O)C(C)O4)CC3CCC23OC32CCC(C(C)=O)C2(C)C1OC(C)=O
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.558
• 储存条件: 2-8C

通关藤苷G靶点实验

查看更多实验

实验名称：Inhibition of Pgp-mediated Hoechst 33343 accumulation in multidrug resistance human H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962898

实验名称：Inhibition of Pgp-mediated Hoechst 33343 accumulation in multidrug resistance human H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962899

实验名称：Inhibition of Pgp-mediated Rh123 accumulation in multidrug resistance human HepG2/Dox... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962896

实验名称：Inhibition of Pgp-mediated Rh123 accumulation in multidrug resistance human HepG2/Dox... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962897

实验名称：Increase in doxorubicin uptake in multidrug resistance human HepG2/Dox cells assessed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962894

实验名称：Increase in doxorubicin uptake in multidrug resistance human HepG2/Dox cells assessed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962895

实验名称：Increase in doxorubicin uptake in multidrug resistance human HepG2/Dox cells assessed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962893

实验名称：Effect on P-glycoprotein expression in multidrug resistance human HepG2/Dox cells at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL962900

实验名称：Effect on doxorubicin-induced cell cycle arrest in multidrug resistance human HepG2/D... 来源：ChEMBL 靶标：N/A External Id：CHEMBL963709

实验名称：Effect on doxorubicin-induced cell cycle arrest in multidrug resistance human HepG2/D... 来源：ChEMBL 靶标：N/A External Id：CHEMBL963710

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通关藤苷G英文别名

• (1R,3aR,4aS,6aS,8S,10aS,10bS,11S,12S,12aS)-12-acetoxy-1-acetyl-8-(((2R,4R,5R,6R)-5-(((2S,3R,4R,5R,6R)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10a,12a-dimethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[1,10a-b]oxiren-11-yl (E)-2-methylbut-2-enoate
• (3β,5α,11α,12β,14β)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl (2E)-2-methyl- 2-butenoate
• (3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl (2E)-2 -methyl-2-butenoate
• Tenacissoside G