环(脯氨酸-甘氨酸)二肽

• 常用名: 环(脯氨酸-甘氨酸)二肽
• 英文名: Cyclo(Pro-Gly)
• CAS号: 19179-12-5
• 分子量: 154.167
• 密度: 1.3±0.1 g/cm3
• 沸点: 447.9±34.0 °C at 760 mmHg
• 分子式: C₇H₁₀N₂O₂
• 熔点: N/A
• 闪点: 224.7±25.7 °C

环(脯氨酸-甘氨酸)二肽用途

Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) 是可从绿藻 Ulva prolifera 中提取得到的一种生物碱,对常见的有害红潮微藻具有抗藻活性。Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) 具有抗失忆和神经保护活性。

环(脯氨酸-甘氨酸)二肽名称

• 中文名: 六氢吡咯并[1,2-a]吡嗪-1,4-二酮
• 英文名: 2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

环(脯氨酸-甘氨酸)二肽生物活性

• 描述: Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) 是可从绿藻 Ulva prolifera 中提取得到的一种生物碱,对常见的有害红潮微藻具有抗藻活性。Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) 具有抗失忆和神经保护活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 环-(Pro-Gly)(0.1和10mg/kg,ip)似乎是一种促进记忆的物质,它在大鼠脑中的存在表明存在一种新的记忆调节机制[3]。
• 参考文献:

  [1]. Ying-ying Sun, et al. Isolation, Purification, and Identification of Antialgal Substances in Green Alga Ulva Prolifera for Antialgal Activity Against the Common Harmful Red Tide Microalgae. Environ Sci Pollut Res Int. 2016 Jan;23(2):1449-59.

  [2]. Fumitaka Hayasaka, et al. Production Method for Cyclic Dipeptide Derived from Native Collagen. Food Science and Technology Research, 22 (4), 477-483, 2016.

  [3]. T A Gudasheva, et al. Identification of a Novel Endogenous Memory Facilitating Cyclic Dipeptide Cyclo-Prolylglycine in Rat Brain. FEBS Lett. 1996 Aug 5;391(1-2):149-52.

环(脯氨酸-甘氨酸)二肽物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 447.9±34.0 °C at 760 mmHg
• 分子式: C₇H₁₀N₂O₂
• 分子量: 154.167
• 闪点: 224.7±25.7 °C
• 精确质量: 154.074234
• PSA: 52.90000
• LogP: -2.74
• InChIKey: OWOHLURDBZHNGG-UHFFFAOYSA-N
• SMILES: O=C1NCC(=O)N2CCCC12
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.569
• 储存条件: 室温，干燥

环(脯氨酸-甘氨酸)二肽安全信息

• 海关编码: 2933990090

环(脯氨酸-甘氨酸)二肽海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

环(脯氨酸-甘氨酸)二肽靶点实验

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实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

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环(脯氨酸-甘氨酸)二肽英文别名

• Cyclo-Gly-Pro
• cyclo-Glycyl-L-Proline
• DL-2,5-Dioxo-1,4-diazabicyclo<4.3.0>nonane
• Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
• Gly-Pro-diketopiperazine
• Glycyl-L-proline lactam
• cyclo-GP
• cyclo-L-prolylglycine