JAK2抑制剂V,Z3

• 常用名: JAK2抑制剂V,Z3
• 英文名: NSC 42834
• CAS号: 195371-52-9
• 分子量: 344.449
• 密度: 1.1±0.1 g/cm3
• 沸点: 520.4±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄N₂O
• 熔点: N/A
• 闪点: 263.0±36.5 °C

JAK2抑制剂V,Z3用途

Z3(NSC 42834)是新型Jak2特异性抑制剂,能以剂量依赖的形式抑制Jak2-V617F和Jak2-WT的自磷酸化。

JAK2抑制剂V,Z3名称

• 中文名: NSC 42834
• 英文名: 2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one

JAK2抑制剂V,Z3生物活性

• 描述: Z3(NSC 42834)是新型Jak2特异性抑制剂,能以剂量依赖的形式抑制Jak2-V617F和Jak2-WT的自磷酸化。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  JAK2-WT:15 μM (IC50)

  JAK2-V617F:28 μM (IC50)

• 参考文献:

  [1]. Jacqueline Sayyah, Andrew Magis, David A. Ostrov, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth . Mol Cancer Ther 2008;7(8):2308-18.

  [2]. Jacqueline Sayyah, Peter P. Sayeski. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. Current Oncology Reports. 2009, 11(2): 117-124.

  [3]. Ehab Atallah , Srdan Verstovsek . Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms. Expert Review of Anticancer Therapy. 2009,9 (5):663-670.

JAK2抑制剂V,Z3物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 520.4±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄N₂O
• 分子量: 344.449
• 闪点: 263.0±36.5 °C
• 精确质量: 344.188873
• PSA: 42.85000
• LogP: 4.06
• InChIKey: SETYDCSRABYHSW-UHFFFAOYSA-N
• SMILES: CC(CCc1ccccn1)(CCc1ccccn1)C(=O)c1ccccc1
• 外观性状: light yellow oil
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.586
• 储存条件: -20℃

JAK2抑制剂V,Z3安全信息

JAK2抑制剂V,Z3靶点实验

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JAK2抑制剂V,Z3英文别名

• 2-methyl-1-phenyl-4-(pyridin-2-yl)-2-[2-(pyridin-2-yl)ethyl]butan-1-one
• 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone
• JAK2 Inhibitor V,Z3
• HMS3092H09
• NSC 42834