JAK2抑制剂V,Z3

更新时间：2025-08-22 18:37:20

JAK2抑制剂V,Z3结构式	常用名	JAK2抑制剂V,Z3	英文名	NSC 42834
	CAS号	195371-52-9	分子量	344.449
	密度	1.1±0.1 g/cm3	沸点	520.4±50.0 °C at 760 mmHg
	分子式	C₂₃H₂₄N₂O	熔点	N/A
	MSDS	N/A	闪点	263.0±36.5 °C

JAK2抑制剂V,Z3用途

Z3(NSC 42834)是新型Jak2特异性抑制剂，能以剂量依赖的形式抑制Jak2-V617F和Jak2-WT的自磷酸化。

中文名	NSC 42834
英文名	2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
英文别名	更多

描述	Z3(NSC 42834)是新型Jak2特异性抑制剂,能以剂量依赖的形式抑制Jak2-V617F和Jak2-WT的自磷酸化。
相关类别	研究领域 >> 癌症
靶点实验	JAK2-WT:15 μM (IC50) JAK2-V617F:28 μM (IC50)
参考文献	[1]. Jacqueline Sayyah, Andrew Magis, David A. Ostrov, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth . Mol Cancer Ther 2008;7(8):2308-18. [2]. Jacqueline Sayyah, Peter P. Sayeski. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. Current Oncology Reports. 2009, 11(2): 117-124. [3]. Ehab Atallah , Srdan Verstovsek . Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms. Expert Review of Anticancer Therapy. 2009,9 (5):663-670.

密度	1.1±0.1 g/cm3
沸点	520.4±50.0 °C at 760 mmHg
分子式	C₂₃H₂₄N₂O
分子量	344.449
闪点	263.0±36.5 °C
精确质量	344.188873
PSA	42.85000
LogP	4.06
InChIKey	SETYDCSRABYHSW-UHFFFAOYSA-N
SMILES	CC(CCc1ccccn1)(CCc1ccccn1)C(=O)c1ccccc1
外观性状	light yellow oil
蒸汽压	0.0±1.4 mmHg at 25°C
折射率	1.586
储存条件	-20℃

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