SLF

• 常用名: SLF
• 英文名: SLF
• CAS号: 195513-96-3
• 分子量: 524.648
• 密度: 1.2±0.1 g/cm3
• 沸点: 656.9±65.0 °C at 760 mmHg
• 分子式: C₃₀H₄₀N₂O₆
• 熔点: N/A
• 闪点: 351.1±34.3 °C

SLF用途

SLF 是 FK506 结合蛋白 (FKBP) 的合成配体,对 FKBP51 的亲和力为 3.1 μM,对 FKBP12 的 IC50 为 0.22 μM,可用于合成 PROTAC 分子。

SLF名称

• 英文名: 1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimet hyl-2-oxopentanoyl)-2-piperidinecarboxylate

SLF生物活性

• 描述: SLF 是 FK506 结合蛋白 (FKBP) 的合成配体,对 FKBP51 的亲和力为 3.1 μM,对 FKBP12 的 IC50 为 0.22 μM,可用于合成 PROTAC 分子。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.

  [2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.

  [3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

SLF物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 656.9±65.0 °C at 760 mmHg
• 分子式: C₃₀H₄₀N₂O₆
• 分子量: 524.648
• 闪点: 351.1±34.3 °C
• 精确质量: 524.288635
• PSA: 108.16000
• LogP: 3.63
• InChIKey: IIDSDBBDZNDWCN-BJKOFHAPSA-N
• SMILES: CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.559
• 储存条件: -20°C

SLF靶点实验

查看更多实验

实验名称：Binding affinity to FKBP12 by fluorescence polarization assay 来源：ChEMBL 靶标：Peptidyl-prolyl cis-trans isomerase FKBP1A External Id：CHEMBL2061149

实验名称：Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay 来源：ChEMBL 靶标：Peptidyl-prolyl cis-trans isomerase FKBP5 External Id：CHEMBL2061150

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay 来源：ChEMBL 靶标：Peptidyl-prolyl cis-trans isomerase FKBP4 External Id：CHEMBL2061151

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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SLF英文别名

• (1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-piperidinecarboxylate