马卡因; 高丽槐素

• 常用名: 马卡因; 高丽槐素
• 英文名: Maackiain
• CAS号: 19908-48-6
• 分子量: 284.263
• 密度: 1.5±0.1 g/cm3
• 沸点: 436.2±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₅
• 熔点: N/A
• 闪点: 217.6±28.7 °C

马卡因; 高丽槐素用途

Maackiain (DL-Maackiain) 分离自Maackia amurensis Rupr.et Maxim。Maackiain (DL-Maackiain) 是一种针对埃及伊蚊的杀幼虫剂,其 LD50 为 21.95 μg/ ml。Maackiain (DL-Maackiain) 诱导 DNA 断裂为寡核小体大小的片段,类似于凋亡特征,如 HL-60 细胞。

马卡因; 高丽槐素名称

• 中文名: 高丽槐素
• 英文名: (+)-Maackiain
• 中文别名: 马卡因 | 马卡因

马卡因; 高丽槐素生物活性

• 描述: Maackiain (DL-Maackiain) 分离自Maackia amurensis Rupr.et Maxim。Maackiain (DL-Maackiain) 是一种针对埃及伊蚊的杀幼虫剂,其 LD50 为 21.95 μg/ ml。Maackiain (DL-Maackiain) 诱导 DNA 断裂为寡核小体大小的片段,类似于凋亡特征,如 HL-60 细胞。
• 相关类别:
  研究领域 >> 感染
• 靶点实验:

  LD50: 21.95 µg/mL (Aedes aegypti mosquito.xp Parasitol)[1]

• 参考文献:

  [1]. Bezerra-Silva PC, et al. Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.xp Parasitol. 2015 Jun;153:160-4.

  [2]. Aratanechemuge Y, et al. Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.Oncol Rep. 2004 Dec;12(6):1183-8.

马卡因; 高丽槐素物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 436.2±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₅
• 分子量: 284.263
• 闪点: 217.6±28.7 °C
• 精确质量: 284.068481
• PSA: 57.15000
• LogP: 2.79
• InChIKey: HUKSJTUUSUGIDC-UHFFFAOYSA-N
• SMILES: Oc1ccc2c(c1)OCC1c3cc4c(cc3OC21)OCO4
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.677
• 储存条件: 2-8C

马卡因; 高丽槐素靶点实验

查看更多实验

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3867995

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3867997

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3867998

实验名称：Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1004272

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3867999

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3868000

实验名称：Anthelmintic activity against Ancylostoma ceylanicum isolated from infected Syrian ha... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3868001

实验名称：Effect on Syrian hamster splenocytes proliferation assessed as stimulation index by B... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3868002

实验名称：Cytotoxicity against human Daudi cells assessed as cell viability after 72 hrs by MTT... 来源：ChEMBL 靶标：Daudi External Id：CHEMBL962454

实验名称：Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT ... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL962452

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马卡因; 高丽槐素英文别名

• rac-maackiain
• 6a,12a-Dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol
• 6a,12a-Dihydro-6H-[1,3]dioxolo[4',5':5,6][1]benzofuro[3,2-c]chromen-3-ol
• 4-Chlorobenzamideoxime
• maackiain
• (6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol
• 6a,12a-Dihydro-6H-(1,3)dioxolo(5,6)benzofuro(3,2-c)chromen-3-ol
• demethylpterocarpin
• 6a,12a-Dihydro-6H-(1,3)dioxolo(5,6)benzofuro(3,2-c)(1)benzopyran-3-ol
• (±)-Maackiain
• dl-Maackiain