Asoprisnil

• 常用名: Asoprisnil
• 英文名: Asoprisnil
• CAS号: 199396-76-4
• 分子量: 449.58200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₅NO₄
• 熔点: N/A
• 闪点: N/A

Asoprisnil用途

Asoprisnil (J867) 是一种选择性孕激素受体 (progesterone receptor) 调节剂,对动物和人类中各种孕酮靶向组织具有混合的孕酮激动剂和拮抗剂作用。

Asoprisnil名称

• 英文名: (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Asoprisnil生物活性

• 描述: Asoprisnil (J867) 是一种选择性孕激素受体 (progesterone receptor) 调节剂,对动物和人类中各种孕酮靶向组织具有混合的孕酮激动剂和拮抗剂作用。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 内分泌
• 参考文献:

  [1]. Stewart EA, et al. Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials. Hum Reprod. 2019 Apr 1;34(4):623-634.

  [2]. Wu XL, et al. Postcoital administration of asoprisnil inhibited embryo implantation and disturbed ultrastructure of endometrium in implantation window in mice. J Huazhong Univ Sci Technolog Med Sci. 2013 Apr;33(2):277-283.

Asoprisnil物理化学性质

• 分子式: C₂₈H₃₅NO₄
• 分子量: 449.58200
• 精确质量: 449.25700
• PSA: 68.12000
• LogP: 5.42580
• InChIKey: GJMNAFGEUJBOCE-MEQIQULJSA-N
• SMILES: COCC1(OC)CCC2C3CCC4=CC(=O)CCC4=C3C(c3ccc(C=NO)cc3)CC21C
• 蒸汽压: 0mmHg at 25°C

Asoprisnil靶点实验

查看更多实验

实验名称：Agonist activity at human MR ligand binding domain receptor expressed in african gree... 来源：ChEMBL 靶标：Mineralocorticoid receptor External Id：CHEMBL935182

实验名称：Agonist activity at human ER ligand binding domain expressed in african green monkey ... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL935184

实验名称：Antagonist activity against progesterone receptor in human T47D cells by alkaline pho... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL2216251

实验名称：Antagonist activity at progesterone receptor in orally dosed ovariectomized Sprague-D... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1680626

实验名称：Antagonist activity at progesterone receptor in estrogen-primed immature New Zealand ... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL1680627

实验名称：Agonist activity at human AR ligand binding domain expressed in african green monkey ... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL934260

实验名称：Agonist activity at progesterone receptor in estrogen-primed immature New Zealand Whi... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL1680629

实验名称：Agonist activity at human GR ligand binding domain expressed in african green monkey ... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL935180

实验名称：Agonist activity at androgen receptor by cellular reporter gene assay 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL2216242

实验名称：Agonist activity at progesterone receptor by cellular reporter gene assay 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL2216243

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Asoprisnil英文别名

• J867
• Benzaldehyde,4-((11beta,17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl)-,1-oxime,(C(E))
• Asoprisnil
• 11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one
• Asoprisnil (USAN/INN)