AZ13705339

• 常用名: AZ13705339
• 英文名: AZ 13705339
• CAS号: 2016806-57-6
• 分子量: 629.747
• 密度: 1.4±0.1 g/cm3
• 沸点: 868.7±75.0 °C at 760 mmHg
• 分子式: C₃₃H₃₆FN₇O₃S
• 熔点: N/A
• 闪点: 479.2±37.1 °C

AZ13705339用途

AZ13705339是一种有效的选择性PAK1抑制剂,IC50为0.33 nM,选择性比Src,FGFR1,KDR和PAK4高14,470,4100和2600倍；抑制MCF10A细胞系中细胞pPAK1的抑制,IC50为59 nM。

AZ13705339名称

• 英文名: 2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile

AZ13705339生物活性

• 描述: AZ13705339是一种有效的选择性PAK1抑制剂,IC50为0.33 nM,选择性比Src,FGFR1,KDR和PAK4高14,470,4100和2600倍；抑制MCF10A细胞系中细胞pPAK1的抑制,IC50为59 nM。
• 参考文献: References 1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. View Related Products by Target p21-activated Kinase (PAK)

AZ13705339物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 868.7±75.0 °C at 760 mmHg
• 分子式: C₃₃H₃₆FN₇O₃S
• 分子量: 629.747
• 闪点: 479.2±37.1 °C
• 精确质量: 629.258423
• LogP: 1.96
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.682

AZ13705339靶点实验

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实验名称：Activity at CaV-L (unknown origin) at <1 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL3865559

实验名称：Activity at alpha-1B adrenergic receptor (unknown origin) at <1 uM 来源：ChEMBL 靶标：Alpha-1B adrenergic receptor External Id：CHEMBL3865560

实验名称：Activity at alpha-2C adrenergic receptor (unknown origin) at <1 uM 来源：ChEMBL 靶标：Alpha-2C adrenergic receptor External Id：CHEMBL3865561

实验名称：Intrinsic clearance in rat hepatocytes assessed per million cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3865562

实验名称：Activity at muscarinic acetylcholine receptor M5 (unknown origin) at <1 uM 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL3865555

实验名称：Activity at dopamine receptor D3 (unknown origin) at <1 uM 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL3865556

实验名称：Activity at 5HT2B receptor (unknown origin) at <1 uM 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL3865557

实验名称：Activity at dopamine transporter (unknown origin) at <1 uM 来源：ChEMBL 靶标：Sodium-dependent dopamine transporter External Id：CHEMBL3865558

实验名称：Growth inhibition of human A549 cells 来源：ChEMBL 靶标：A549 External Id：CHEMBL4271275

实验名称：Inhibition of N-Terminal His6-tagged full length recombinant human FYN expressed in b... 来源：ChEMBL 靶标：Tyrosine-protein kinase Fyn External Id：CHEMBL3865543

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AZ13705339英文别名

• 2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile