澳洲茄边碱

• 常用名: 澳洲茄边碱
• 英文名: Solamargine
• CAS号: 20311-51-7
• 分子量: 868.059
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₄₅H₇₃NO₁₅
• 熔点: N/A
• 闪点: N/A

澳洲茄边碱用途

澳洲茄边碱(Solamargine)是从传统中药龙葵中提取的生物碱苷,被报道对多种癌细胞有诱导凋亡的作用。

澳洲茄边碱名称

• 中文名: 澳洲茄边碱
• 英文名: Solamargine

澳洲茄边碱生物活性

• 描述: 澳洲茄边碱(Solamargine)是从传统中药龙葵中提取的生物碱苷,被报道对多种癌细胞有诱导凋亡的作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Sani IK, et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Mar 27;29(5):893-900.

  [2]. Zhou Y, et al. Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Tumour Biol. 2014 Aug;35(8):8169-78.

  [3]. Ding X, et al. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012 Jan 31;139(2):599-604.

澳洲茄边碱物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₄₅H₇₃NO₁₅
• 分子量: 868.059
• 精确质量: 867.498047
• PSA: 238.48000
• LogP: 7.18
• InChIKey: MBWUSSKCCUMJHO-ZGXDEBHDSA-N
• SMILES: CC1CCC2(NC1)OC1CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C
• 折射率: 1.619
• 储存条件: -20°C

澳洲茄边碱靶点实验

查看更多实验

实验名称：Cytotoxicity against human HL-7702 cells assessed as cell viability after 24 hrs by M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3128827

实验名称：Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3128828

实验名称：Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3128829

实验名称：Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs by MTT ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3128830

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Suppression of gastric emptying in CMC-Na-loaded mouse at 25 mg/kg, po after 30 mins 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL908496

实验名称：Suppression of gastric emptying in CMC-Na-loaded mouse at 50 mg/kg, po after 30 mins 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL908497

实验名称：Cytotoxicity against human PLC/PRF/5 cells by microassay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL949785

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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澳洲茄边碱英文别名

• SOLAMERGINE
• Solamargine
• Solamargin
• (3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside