JNJ-55511118

• 常用名: JNJ-55511118
• 英文名: JNJ 55511118
• CAS号: 2036081-86-2
• 分子量: 328.674
• 密度: 1.5±0.1 g/cm3
• 沸点: 279.7±40.0 °C at 760 mmHg
• 分子式: C₁₄H₈ClF₃N₂O₂
• 熔点: N/A
• 闪点: 123.0±27.3 °C

JNJ-55511118用途

JNJ-55511118(JNJ55511118)是一种选择性口服AMPA受体,含有TARP-γ8负调节因子,Ki为26 nM,对其他无TARP的AMPAR和AMPAR与其他TARP或CNIH2共表达无显着活性；表现出优异的药代动力学特性并在口服给药后实现高受体占据,表现出脑电图上某些条带的强烈减少,短暂的过度运动,旋转棒上没有运动损伤,以及体内学习和记忆的轻度损伤。

JNJ-55511118名称

• 英文名: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one

JNJ-55511118生物活性

• 描述: JNJ-55511118(JNJ55511118)是一种选择性口服AMPA受体,含有TARP-γ8负调节因子,Ki为26 nM,对其他无TARP的AMPAR和AMPAR与其他TARP或CNIH2共表达无显着活性；表现出优异的药代动力学特性并在口服给药后实现高受体占据,表现出脑电图上某些条带的强烈减少,短暂的过度运动,旋转棒上没有运动损伤,以及体内学习和记忆的轻度损伤。
• 参考文献: References 1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414. 2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. View Related Products by Target iGluR

JNJ-55511118物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 279.7±40.0 °C at 760 mmHg
• 分子式: C₁₄H₈ClF₃N₂O₂
• 分子量: 328.674
• 闪点: 123.0±27.3 °C
• 精确质量: 328.022644
• LogP: 4.29
• InChIKey: COBXSLRIXGQVGS-UHFFFAOYSA-N
• SMILES: O=c1[nH]c2ccc(-c3c(Cl)cccc3OC(F)(F)F)cc2[nH]1
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.560

JNJ-55511118靶点实验

查看更多实验

实验名称：Thiol reactivity in cynomolgus monkey hepatocytes assessed as adduct formation at 10 ... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4200567

实验名称：Thiol reactivity in Beagle dog hepatocytes assessed as adduct formation at 10 uM afte... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4200566

实验名称：Glutathione reactivity in human liver microsomes assessed as GSH adduct formation at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4200569

实验名称：Drug metabolism in CD-1 mouse hepatocytes assessed as oxidative dechlorination by mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4200568

实验名称：Thiol reactivity in cryopreserved human hepatocytes assessed as adduct formation at 1... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4200563

实验名称：Hepatotoxicity in Sprague-Dawley rat assessed as necrosis at 20 to 60 mg/kg, po measu... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4200562

实验名称：Thiol reactivity in CD-1 mouse hepatocytes assessed as adduct formation at 10 uM afte... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4200565

实验名称：Thiol reactivity in Sprague-Dawley rat hepatocytes assessed as adduct formation at 10... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4200564

实验名称：Ex vivo receptor occupancy at GluA/TARPgamma8 in po dosed Sprague-Dawley rat assessed... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4200573

实验名称：Apparent permeability across apical to basolateral side in MDCK-MDR1 cells at 5 uM me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4200551

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JNJ-55511118英文别名

• 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one