![]() JNJ 55511118 structure
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Common Name | JNJ 55511118 | ||
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CAS Number | 2036081-86-2 | Molecular Weight | 328.674 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 279.7±40.0 °C at 760 mmHg | |
Molecular Formula | C14H8ClF3N2O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 123.0±27.3 °C |
Use of JNJ 55511118JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2; demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration, exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo. |
Name | 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one |
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Synonym | More Synonyms |
Description | JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2; demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration, exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo. |
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References | References 1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414. 2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. View Related Products by Target iGluR |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 279.7±40.0 °C at 760 mmHg |
Molecular Formula | C14H8ClF3N2O2 |
Molecular Weight | 328.674 |
Flash Point | 123.0±27.3 °C |
Exact Mass | 328.022644 |
LogP | 4.29 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.560 |
2H-Benzimidazol-2-one, 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro- |
5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one |