TBK1 PROTAC 1

• 常用名: TBK1 PROTAC 1
• 英文名: TBK1 PROTAC 1
• CAS号: 2052306-13-3
• 分子量: 1093.179
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₅₃H₇₄BrN₉O₉S
• 熔点: N/A
• 闪点: N/A

TBK1 PROTAC 1用途

一种新型有效的选择性TBK1-PROTAC,DC50为12 nM,选择性降解TBK1,对相关激酶IKKε具有优异的选择性；一种评估TBK1作为突变K-Ras癌细胞靶标的化学工具。

TBK1 PROTAC 1名称

• 中文名: TBK1PROTAC®3i
• 英文名: N-[(3-{4-[3-(4-{[5-Bromo-4-({3-[(cyclobutylcarbonyl)(methyl)amino]propyl}amino)-2-pyrimidinyl]amino}phenoxy)propoxy]butoxy}propoxy)acetyl]-3-methylvalyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]prolinamide

TBK1 PROTAC 1生物活性

• 描述: 一种新型有效的选择性TBK1-PROTAC,DC50为12 nM,选择性降解TBK1,对相关激酶IKKε具有优异的选择性；一种评估TBK1作为突变K-Ras癌细胞靶标的化学工具。
• 参考文献: References 1. Crew AP, et al. J Med Chem. 2017 Jul 10. doi: 10.1021/acs.jmedchem.7b00635. View Related Products by Target PROTAC

TBK1 PROTAC 1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₅₃H₇₄BrN₉O₉S
• 分子量: 1093.179
• 精确质量: 1091.451294
• LogP: 4.09
• InChIKey: QMGHHBHPDDAGGO-IIWOMYBWSA-N
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1
• 折射率: 1.604

TBK1 PROTAC 1靶点实验

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实验名称：Antiproliferative activity against human H23 cells harboring K-Ras mutant at 10 uM af... 来源：ChEMBL 靶标：NCI-H23 External Id：CHEMBL4219648

实验名称：Induction of VHL-mediated TBK1 degradation in human HCC827 cells harboring wild-type ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL4219647

实验名称：Antiproliferative activity against human NCI-H1792 cells harboring K-Ras mutant at 10... 来源：ChEMBL 靶标：NCI-H1792 External Id：CHEMBL4219650

实验名称：Antiproliferative activity against human A549 cells harboring K-Ras mutant at 10 uM a... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4219649

实验名称：Induction of VHL-mediated TBK1 degradation in human H23 cells harboring K-Ras mutant ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL4219644

实验名称：Induction of VHL-mediated IKKepsilon degradation in human Panc02.13 cells up to 3 uM ... 来源：ChEMBL 靶标：Inhibitor of nuclear factor kappa-B kinase subunit epsilon External Id：CHEMBL4219643

实验名称：Induction of VHL-mediated TBK1 degradation in human H2110 cells harboring wild-type K... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL4219646

实验名称：Induction of VHL-mediated TBK1 degradation in human H1792 cells harboring K-Ras mutan... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL4219645

实验名称：Induction of VHL-mediated TBK1 degradation in human Panc02.13 cells assessed as decre... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL4219655

实验名称：Antiproliferative activity against human HCC827 cells harboring wild-type K-Ras at 10... 来源：ChEMBL 靶标：HCC827 External Id：CHEMBL4219652

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TBK1 PROTAC 1英文别名

• N-[(3-{4-[3-(4-{[5-Bromo-4-({3-[(cyclobutylcarbonyl)(methyl)amino]propyl}amino)-2-pyrimidinyl]amino}phenoxy)propoxy]butoxy}propoxy)acetyl]-3-methylvalyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]prolinamide