ML-​226

• 常用名: ML-​226
• 英文名: ML-​226
• CAS号: 2055172-43-3
• 分子量: 390.478
• 密度: 1.2±0.1 g/cm3
• 沸点: 576.8±42.0 °C at 760 mmHg
• 分子式: C₂₃H₂₆N₄O₂
• 熔点: N/A
• 闪点: 302.7±27.9 °C

ML-​226用途

ML226是一种有效的含α/β水解酶结构域的蛋白质11(ABHD11)体外和原位抑制剂,IC50分别为15和0.68 nM[1]。

ML-​226名称

• 英文名: ML-226

ML-​226生物活性

• 描述: ML226是一种有效的含α/β水解酶结构域的蛋白质11(ABHD11)体外和原位抑制剂,IC50分别为15和0.68 nM[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hsu KL, et al. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

ML-​226物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 576.8±42.0 °C at 760 mmHg
• 分子式: C₂₃H₂₆N₄O₂
• 分子量: 390.478
• 闪点: 302.7±27.9 °C
• 精确质量: 390.205566
• LogP: 3.17
• InChIKey: DGRUIUDIVFCWMX-UHFFFAOYSA-N
• SMILES: CCC1CCCCN1C(=O)n1ncc(C(O)(c2ccccc2)c2ccccc2)n1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.637
• 储存条件: -20°C，密闭，干燥

ML-​226靶点实验

查看更多实验

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

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ML-​226英文别名

• ML-226
• (2-Ethyl-1-piperidinyl){4-[hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}methanone