Anticancer agent 168

• 常用名: Anticancer agent 168
• 英文名: Anticancer agent 168
• CAS号: 207399-56-2
• 分子量: 362.72
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₁ClN₂O₆
• 熔点: N/A
• 闪点: N/A

Anticancer agent 168用途

Anticancer agent 168 (compound d16) 是 DNA2 的抑制剂。Anticancer agent 168 导致细胞凋亡 (apoptosis)、细胞周期主要停留在 s 期,在携带 mutp53 的肿瘤中并表现出抗癌活性并克服化疗耐药。

Anticancer agent 168名称

• 英文名: Anticancer agent 168

Anticancer agent 168生物活性

• 描述: Anticancer agent 168 (compound d16) 是 DNA2 的抑制剂。Anticancer agent 168 导致细胞凋亡 (apoptosis)、细胞周期主要停留在 s 期,在携带 mutp53 的肿瘤中并表现出抗癌活性并克服化疗耐药。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3(10):2096-2112.

Anticancer agent 168物理化学性质

• 分子式: C₁₆H₁₁ClN₂O₆
• 分子量: 362.72

Anticancer agent 168靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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