Antifungal agent 31

• 常用名: Antifungal agent 31
• 英文名: Antifungal agent 31
• CAS号: 2077083-94-2
• 分子量: 492.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₂F₂N₆O₃
• 熔点: N/A
• 闪点: N/A

Antifungal agent 31用途

抗真菌剂31(化合物12)是一种具有吡咯三嗪酮支架的强效口服三唑类抗真菌剂。抗真菌剂31对念珠菌属和丝状真菌具有抗真菌活性。抗真菌药物31显著降低了两种致死性全身感染小鼠模型的死亡率和肾脏真菌负荷[1]。

Antifungal agent 31名称

• 英文名: Antifungal agent 31

Antifungal agent 31生物活性

• 描述: 抗真菌剂31(化合物12)是一种具有吡咯三嗪酮支架的强效口服三唑类抗真菌剂。抗真菌剂31对念珠菌属和丝状真菌具有抗真菌活性。抗真菌药物31显著降低了两种致死性全身感染小鼠模型的死亡率和肾脏真菌负荷[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Montoir D, et al. New azole antifungals with a fused triazinone scaffold. Eur J Med Chem. 2020 Mar 1;189:112082.

Antifungal agent 31物理化学性质

• 分子式: C₂₅H₂₂F₂N₆O₃
• 分子量: 492.48

Antifungal agent 31靶点实验

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实验名称：Antifungal activity against fluconazole-resistant Candida albicans DSY735 over expres... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL4684827

实验名称：Antifungal activity against fluconazole-susceptible Candida albicans CAAL93 assessed ... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL4684826

实验名称：Antifungal activity against fluconazole-resistant Candida krusei CAKR7 assessed as re... 来源：ChEMBL 靶标：Pichia kluyveri External Id：CHEMBL4684829

实验名称：Antifungal activity against fluconazole-resistant Candida albicans DSY292 harboring E... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL4684828

实验名称：Antifungal activity against fluconazole-sensitive Candida glabrata CAGL2 assessed as ... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL4684831

实验名称：Antifungal activity against fluconazole-resistant Candida krusei CAKR8 assessed as re... 来源：ChEMBL 靶标：Pichia kluyveri External Id：CHEMBL4684830

实验名称：Antifungal activity against Aspergillus fumigatus ASFU7 assessed as reduction in micr... 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL4684833

实验名称：Antifungal activity against Aspergillus fumigatus ASFU76 assessed as reduction in mic... 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL4684832

实验名称：Antifungal activity against Candida albicans CAAL93 infected in Swiss mouse assessed ... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL4684867

实验名称：Toxicity in CRL:WI rat assessed as weight gain at 300 mg/kg, po up to 14 days 来源：ChEMBL 靶标：N/A External Id：CHEMBL4684866

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