CDK2 inhibitor 73

• 常用名: CDK2 inhibitor 73
• 英文名: CDK2 inhibitor 73
• CAS号: 2079895-42-2
• 分子量: 442.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₈N₆O₂S
• 熔点: N/A
• 闪点: N/A

CDK2 inhibitor 73用途

CDK2-IN-4 是一种有效选择性的 CDK2 抑制剂,对 CDK2/cyclin A 的 IC50 值为 44 nM,选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。

CDK2 inhibitor 73名称

• 英文名: CDK2-IN-4

CDK2 inhibitor 73生物活性

• 描述: CDK2-IN-4 是一种有效选择性的 CDK2 抑制剂,对 CDK2/cyclin A 的 IC50 值为 44 nM,选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  cdk2/cyclin A:44 nM (IC50)

  Cdk1/cyclin B:86 μM (IC50)

• 参考文献:

  [1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.

CDK2 inhibitor 73物理化学性质

• 分子式: C₂₃H₁₈N₆O₂S
• 分子量: 442.49
• 外观性状: 淡黄色固体
• 储存条件: 2-8℃

CDK2 inhibitor 73靶点实验

查看更多实验

实验名称：Growth inhibition of Rb-proficient human MDA-MB-231 cells at 30 uM after 120 hrs by S... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4004964

实验名称：Inhibition of recombinant human full-length C-terminal His6-tagged Cdk7/recombinant h... 来源：ChEMBL 靶标：Cyclin-H External Id：CHEMBL4004963

实验名称：Growth inhibition of Rb-proficient human SK-UT-1B cells at 30 uM after 120 hrs by SRB... 来源：ChEMBL 靶标：Skut1B External Id：CHEMBL4004966

实验名称：Growth inhibition of Rb-proficient human SJSA1 cells at 30 uM after 120 hrs by SRB as... 来源：ChEMBL 靶标：SJSA-1 External Id：CHEMBL4004965

实验名称：Inhibition of CDK2/cyclin E (unknown origin) using peptide substrate in presence of [... 来源：ChEMBL 靶标：G1/S-specific cyclin-E1 External Id：CHEMBL4739334

实验名称：Inhibition of Cdk4/Cyclin D (unknown origin) relative to untreated control 来源：ChEMBL 靶标：N/A External Id：CHEMBL4004962

实验名称：Inhibition of recombinant human full-length C-terminal His6-tagged Cdk9/human full-le... 来源：ChEMBL 靶标：Cyclin-dependent kinase 9 External Id：CHEMBL4004961

实验名称：Inhibition of CDK2/cyclin A2 (unknown origin) using FAM-labeled peptide and ATP as su... 来源：ChEMBL 靶标：Cyclin-A2 External Id：CHEMBL4738616

实验名称：Antiproliferative activity against human A2058 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：A2058 External Id：CHEMBL4738617

实验名称：Antiproliferative activity against human K562 cells assessed as cell viability at 10 ... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4739346

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