PARP1-IN-7

更新时间：2025-11-24 20:09:39

PARP1-IN-7用途

PARP1-IN-7是聚ADP核糖聚合酶-1(PARP1)作为抗癌剂的抑制剂。

英文名	PARP1-IN-7

描述	PARP1-IN-7是聚ADP核糖聚合酶-1(PARP1)作为抗癌剂的抑制剂。
相关类别	研究领域 >> 癌症信号通路 >> 表观遗传学 >> PARP 信号通路 >> 细胞周期/DNA损伤 >> PARP
参考文献	[1]. Karche NP, et al. Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization. Bioorg Med Chem. 2020 Dec 15;28(24):115819.

分子式	C₂₄H₂₃N₅O
分子量	397.47
InChIKey	IBBZXRLLZKUNIM-HXUWFJFHSA-N
SMILES	N#Cc1ccc(N2CCN(C3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)cc1

实验名称：Inhibition of NIK (unknown origin) at 10 uM
来源：ChEMBL
靶标：Mitogen-activated protein kinase kinase kinase 14
External Id：CHEMBL4676724

实验名称：Toxicity against SCID/nude mouse xenografted with human MDA-MB-436 cells harboring BR...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676723

实验名称：Toxicity in rat assessed as NOAEL for CNS effect
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676726

实验名称：Toxicity in rat assessed as NOAEL
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676725

实验名称：Selectivity index, ratio of IC50 for inhibition of N-terminal GST-tagged human PARP2 ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676728

实验名称：Toxicity in rat assessed as NOAEL for respiratory effect
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676727

实验名称：Toxicity against SCID/nude mouse xenografted with human SK-ES-1 cells harboring EWSF1...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676730

实验名称：Toxicity against SCID/nude mouse xenografted with human CAPAN-1 cells harboring BRCA ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4676729

实验名称：Antitumor activity against human CAPAN1 cells xenografted in SCID/nude mouse assessed...
来源：ChEMBL
靶标：CAPAN-1
External Id：CHEMBL4676716

实验名称：Antitumor activity against human CAPAN1 cells xenografted in SCID/nude mouse assessed...
来源：ChEMBL
靶标：CAPAN-1
External Id：CHEMBL4676715

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