c-met-IN-1

• 常用名: c-met-IN-1
• 英文名: c-met-IN-1
• CAS号: 2084836-84-8
• 分子量: 640.70
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₃₇FN₆O₅
• 熔点: N/A
• 闪点: N/A

c-met-IN-1用途

c-met-IN-1 (compound 16) 是一种高效选择性的 c-Met 抑制剂,IC50 值为 1.1 nM,具有抗肿瘤活性。

c-met-IN-1名称

• 英文名: c-met-IN-1

c-met-IN-1生物活性

• 描述: c-met-IN-1 (compound 16) 是一种高效选择性的 c-Met 抑制剂,IC50 值为 1.1 nM,具有抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR
• 靶点实验:

  IC50: 1.1 nM (c-Met)[1]

• 体外研究: c-met-in-1(化合物16)对HT-29、MKN-45和A549细胞具有高选择性和显著的细胞毒性,IC50值分别为0.08μm、0.22μm和0.07μm[1]。
• 参考文献:

  [1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.

c-met-IN-1物理化学性质

• 分子式: C₃₅H₃₇FN₆O₅
• 分子量: 640.70
• 储存条件: 2-8°C，密封，干燥

c-met-IN-1靶点实验

查看更多实验

实验名称：Potency index, ratio of foretinib IC50 to compound IC50 for human HT-29 cells 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL3874960

实验名称：Potency index, ratio of foretinib IC50 to compound IC50 for human MKN45 cells 来源：ChEMBL 靶标：MKN-45 External Id：CHEMBL3874961

实验名称：Potency index, ratio of foretinib IC50 to compound IC50 for human A549 cells 来源：ChEMBL 靶标：A549 External Id：CHEMBL3874962

实验名称：Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3874951

实验名称：Cytotoxicity against human A549 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3874952

实验名称：Inhibition of c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 ... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL3874953

实验名称：Potency index, ratio of foretinib IC50 to compound IC50 for c-MET (unknown origin) 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL3874954

实验名称：Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3874950

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