PPARγ/δ modulator 1

• 常用名: PPARγ/δ modulator 1
• 英文名: PPARγ/δ modulator 1
• CAS号: 2089159-00-0
• 分子量: 607.69
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₈ClIN₆O₃Se
• 熔点: N/A
• 闪点: N/A

PPARγ/δ modulator 1用途

PPARγ/δ调制器1(化合物3e)是一种有效的PPAR调制器。PPARγ/δ调制器1是PPARδ拮抗剂和PPARγ部分激动剂,Ki值分别为14.4 nM和5.31μM。PPARγ/δ调节剂1的EC50分别为7.3μM和12.6μM,用于PPARδ共抑制和脂联素生成[1]。

PPARγ/δ modulator 1名称

• 英文名: PPARγ/δ modulator 1

PPARγ/δ modulator 1生物活性

• 描述: PPARγ/δ调制器1(化合物3e)是一种有效的PPAR调制器。PPARγ/δ调制器1是PPARδ拮抗剂和PPARγ部分激动剂,Ki值分别为14.4 nM和5.31μM。PPARγ/δ调节剂1的EC50分别为7.3μM和12.6μM,用于PPARδ共抑制和脂联素生成[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
  研究领域 >> 代谢疾病
• 靶点实验:

  PPARδ:14.4 nM (Ki)

  PPARγ:5.31 μM (Ki)

• 参考文献:

  [1]. An S, et al. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorg Med Chem. 2020 Jan 1;28(1):115226.

PPARγ/δ modulator 1物理化学性质

• 分子式: C₁₈H₁₈ClIN₆O₃Se
• 分子量: 607.69

PPARγ/δ modulator 1靶点实验

查看更多实验

实验名称：Induction of adipogenesis in human MSC at 10 uM incubated for 5 days cotreated with I... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4610737

实验名称：Binding affinity to GST-tagged human PPARalpha LBD up to 30 uM incubated for 2 to 6 h... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL4610739

实验名称：Induction of adipogenesis in human MSC at 10 uM incubated for 5 days cotreated with I... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4610738

实验名称：Competitive binding affinity to GST-tagged human PPARdelta LBD at 30 uM incubated for... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor delta External Id：CHEMBL4610741

实验名称：Competitive binding affinity to GST-tagged human PPARgamma LBD at 30 uM incubated for... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4610740

实验名称：Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as de... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL4011499

实验名称：Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cel... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL4011496

实验名称：Displacement of [3H]R-PLA from human adenosine A1 receptor expressed in CHO cells aft... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL4011494

实验名称：Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 ce... 来源：ChEMBL 靶标：Adenosine receptor A2a External Id：CHEMBL4011495

实验名称：Induction of adipogenesis in human MSC assessed as increase in size of lipid droplets... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4610743

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