SMYD3-IN-1

更新时间：2025-08-27 19:39:54

SMYD3-IN-1结构式	常用名	SMYD3-IN-1	英文名	SMYD3-IN-1
	CAS号	2095160-79-3	分子量	507.02
	密度	N/A	沸点	N/A
	分子式	C₂₈H₃₁ClN₄O₃	熔点	N/A
	MSDS	N/A	闪点	N/A

SMYD3-IN-1用途

SMYD3-IN-1 (compound 29) 是一种不可逆的、选择性的SMYD3 的抑制剂,其IC50 值为 11.7 nM。

英文名	SMYD3-IN-1

描述	SMYD3-IN-1 (compound 29) 是一种不可逆的、选择性的SMYD3 的抑制剂,其IC50 值为 11.7 nM。
相关类别	信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶研究领域 >> 其他
靶点实验	SMYD3:11.7 nM (IC50)
参考文献	[1]. Huang C, et al. Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. ACS Med Chem Lett. 2019 May 23;10(6):978-984.

分子式	C₂₈H₃₁ClN₄O₃
分子量	507.02

实验名称：Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate a...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase SMYD3
External Id：CHEMBL4306869

实验名称：Apparent intrinsic clearance in mouse liver microsomes measured upto 60 mins by LC-MS...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4306868

实验名称：Metabolic stability in mouse liver microsomes assessed as half life preincubated for ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4306867

实验名称：Apparent intrinsic clearance in human liver microsomes measured upto 60 mins by LC-MS...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4306866

实验名称：Metabolic stability in human liver microsomes assessed as half life preincubated for ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4306865

实验名称：Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase SMYD3
External Id：CHEMBL4306860

实验名称：Downregulation of SMYD3 in human HepG2 cells at 5 to 20 uM incubated for 24 hrs by We...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL4306875

实验名称：Inhibition of SMYD3 in human HepG2 cells assessed as decrease in MAP3K2 methylation a...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase SMYD3
External Id：CHEMBL4306874

实验名称：Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate a...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase SMYD3
External Id：CHEMBL4306871

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