Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]

• 常用名: Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]
• 英文名: Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]
• CAS号: 2097416-92-5
• 分子量: 450.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀F₂N₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]

物理化学性质

• 分子式: C₂₂H₂₀F₂N₈O
• 分子量: 450.4
• InChIKey: GGHDHMVFBOLCFR-UHFFFAOYSA-N
• SMILES: Cc1cnc(Nc2ccnn2C)nc1-c1cn2c(n1)C(=O)N(Cc1ccc(F)c(F)c1)CC2

靶点实验

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实验名称：Solubility of compound in PBS at pH 7.4 after 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4324289

实验名称：1-Octanol-PBS buffer distribution coefficient, log D of compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL4324288

实验名称：Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylatio... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL4324287

实验名称：Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylatio... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL4324286

实验名称：Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate pre... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL4324285

实验名称：Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate pre... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL4324284

实验名称：Clearance in human liver microsomes measured per mg of protein 来源：ChEMBL 靶标：N/A External Id：CHEMBL4324283

实验名称：Inhibition of human ERG 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4324297

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4324296

实验名称：Intrinsic clearance in human hepatocytes measured per million of cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4324295

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