APJ receptor agonist 7

• 常用名: APJ receptor agonist 7
• 英文名: APJ receptor agonist 7
• CAS号: 2100850-28-8
• 分子量: 550.73
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₄₆N₄O₄
• 熔点: N/A
• 闪点: N/A

APJ receptor agonist 7用途

APJ受体激动剂7(化合物37)是一种有效的口服活性APJ(apelin受体)激动剂,Ki为0.059μM。APJ受体激动剂7对钙、cAMP和β-阻遏蛋白的EC50值分别为0.070、0.097和0.063μM[1]。

APJ receptor agonist 7名称

• 英文名: APJ receptor agonist 7

APJ receptor agonist 7生物活性

• 描述: APJ受体激动剂7(化合物37)是一种有效的口服活性APJ(apelin受体)激动剂,Ki为0.059μM。APJ受体激动剂7对钙、cAMP和β-阻遏蛋白的EC50值分别为0.070、0.097和0.063μM[1]。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点实验:

  EC50: 0.063 ± 0.004 μM (Apelin Receptor β-arrestin), 0.070 ± 0.009 μM (Apelin Receptor calcium), 0.097 ± 0.032 μM (Apelin Receptor cAMP), >10 μM (AT1 calcium)[1]

• 参考文献:

  [1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.

APJ receptor agonist 7物理化学性质

• 分子式: C₃₂H₄₆N₄O₄
• 分子量: 550.73

APJ receptor agonist 7靶点实验

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实验名称：Agonist activity at human APJ receptor expressed in CHO cells assessed as inhibition ... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4823532

实验名称：Half life in human pooled liver microsomes at 1 uM incubated up to 120 mins in presen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4823536

实验名称：Agonist activity at human AGTRL1 expressed in CHO-K1 cells assessed as induction of b... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4823534

实验名称：Agonist activity at human APJ receptor stably expressed in CHOK1 cells assessed as in... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4627582

实验名称：Intrinsic clearance in human liver microsomes at 1 uM measured upto 120 mins in prese... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627577

实验名称：Half life in human liver microsomes at 1 uM measured up to 120 mins in presence of NA... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627576

实验名称：Agonist activity at human APJ receptor stably expressed in CHO cells co-expressing Ga... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4627581

实验名称：Agonist activity at human APJ receptor stably expressed in CHO cells assessed as inhi... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4627566

实验名称：Intrinsic clearance in human pooled liver microsomes at 1 uM incubated up to 120 mins... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4823537

实验名称：Agonist activity at human APJ receptor stably expressed in CHOK1 cells assessed as in... 来源：ChEMBL 靶标：Apelin receptor External Id：CHEMBL4627569

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