DRI-C25441

更新时间：2026-07-17 08:06:51

DRI-C25441用途

DRI-C2541是CD40和CD40L相互作用的强效阻断剂,IC50为0.36 μM。DRI-C2541可抑制同种异体抗原诱导的免疫应答[1]。

英文名	DRI-C25441

描述	DRI-C2541是CD40和CD40L相互作用的强效阻断剂,IC50为0.36 μM。DRI-C2541可抑制同种异体抗原诱导的免疫应答[1]。
相关类别	研究领域 >> 炎症/免疫
靶点实验	CD40:0.36 μM (IC50)
参考文献	[1]. Lu H, et, al. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials. Signal Transduct Target Ther. 2020 Sep 23;5(1):213.

分子式	C₃₁H₂₁N₃O₆
分子量	531.51

实验名称：Selectivity ratio of IC50 for human Fc-conjugated TNF-R/FLAG-tagged biotinylated TNFa...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4020648

实验名称：Inhibition of interaction of CD40 (unknown origin) transfected in HEK Blue cells with...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020649

实验名称：Inhibition of human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory p...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020646

实验名称：Inhibition of human Fc-conjugated TNF-R/FLAG-tagged biotinylated TNFalpha protein-pro...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4020647

实验名称：Inhibition of interaction of CD40 in human THP-1 cells with recombinant human CD40L a...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020645

实验名称：Inhibition of human Fc-conjugated Mac1/FLAG-tagged biotinylated CD40L protein-protein...
来源：ChEMBL
靶标：Integrin beta-2
External Id：CHEMBL4020658

实验名称：Ratio of IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulato...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020659

实验名称：Inhibition of interaction of CD40 in promoter/enhancer region of aicda-fused Ds-Red r...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020654

实验名称：Inhibition of interaction of CD40 in human B cells with recombinant human CD40L asses...
来源：ChEMBL
靶标：CD40 ligand
External Id：CHEMBL4020653

实验名称：Cytotoxicity against human THP1 cells assessed as reduction in cell viability at 100 ...
来源：ChEMBL
靶标：THP-1
External Id：CHEMBL4020650

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