2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚

• 常用名: 2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚
• 英文名: WHI-P97
• CAS号: 211555-05-4
• 分子量: 455.10100
• 密度: 1.785
• 沸点: N/A
• 分子式: C₁₆H₁₃Br₂N₃O₃
• 熔点: N/A
• 闪点: N/A

用途

WHI-P97是JAK-3抑制剂。

名称

• 中文名: 2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚
• 英文名: 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

生物活性

• 描述: WHI-P97是JAK-3抑制剂。
• 相关类别:
  研究领域 >> 炎症/免疫
• 靶点实验:

  JAK3:11 μM (IC50)

• 参考文献:

  [1]. Ji KA, Yang MS, Jou I, Shong MH, Joe EH.Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.Glia. 2004 Nov 1;48(2):102-11.

  [2]. Wong WS, Leong KP.Tyrosine kinase inhibitors: a new approach for asthma.Biochim Biophys Acta. 2004 Mar 11;1697(1-2):53-69.

  [3]. Uckun FM, Sudbeck EA, Mao C, Ghosh S, Liu XP, Vassilev AO, Navara CS, Narla RK.Structure-based design of novel anticancer agents.Curr Cancer Drug Targets. 2001 May;1(1):59-71.

  [4]. Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, Uckun FM.Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.Clin Cancer Res. 1999 Jun;5(6):1569-82.

物理化学性质

• 密度: 1.785
• 分子式: C₁₆H₁₃Br₂N₃O₃
• 分子量: 455.10100
• 精确质量: 452.93200
• PSA: 76.50000
• LogP: 4.69420
• InChIKey: YVCXQRVVNQMZEI-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
• 储存条件: -20°C

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

共114条，当前第1页，共12页

1

2

3

4

5

英文别名

• whi-p97
• hms3265e23