Purvalanol B.

• 常用名: Purvalanol B.
• 英文名: Purvalanol B
• CAS号: 212844-54-7
• 分子量: 432.904
• 密度: 1.4±0.1 g/cm3
• 沸点: 660.6±65.0 °C at 760 mmHg
• 分子式: C₂₀H₂₅ClN₆O₃
• 熔点: N/A
• 闪点: 353.3±34.3 °C

Purvalanol B.用途

Purvalanol B(NG-95)是CDK抑制剂,对cdc2/cyclin B,cdk2/cyclin A,cdk2/cyclin E,cdk4/cyclin D1和cdk5-p35的IC50 分别为6,6,9,> 10000和6 nM。

Purvalanol B.名称

• 中文名: (2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇
• 英文名: Purvalanol B,(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purvalanol B.生物活性

• 描述: Purvalanol B(NG-95)是CDK抑制剂,对cdc2/cyclin B,cdk2/cyclin A,cdk2/cyclin E,cdk4/cyclin D1和cdk5-p35的IC50 分别为6,6,9,> 10000和6 nM。
• 相关类别:
  研究领域 >> 癌症
• 靶点:

  cdc2/cyclin B:6 nM (IC50)

  cyclin dependent kinase 1-cyclinB:6 nM (IC50)

  cdk2/cyclin A:6 nM (IC50)

  CDK2/cyclinE:9 nM (IC50)

  CDK5/p35:6 nM (IC50)

  Cdk4/cyclin D1:10000 nM (IC50)

  TrkA:51 nM (IC50)

  TrkB:11 nM (IC50)

• 参考文献:

  [1]. purvalanol B (CID 448991) - Compound BioActivity Data

  [2]. Knockaert M, et al. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 2002 Sep 19;21(42):6413-24.

Purvalanol B.物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 660.6±65.0 °C at 760 mmHg
• 分子式: C₂₀H₂₅ClN₆O₃
• 分子量: 432.904
• 闪点: 353.3±34.3 °C
• 精确质量: 432.167664
• PSA: 125.19000
• LogP: 2.42
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.673
• 储存条件: 2-8℃

Purvalanol B.安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

Purvalanol B.英文别名

• 2-Chloro-4-[(2-{[(2R)-1-hydroxy-3-methylbutan-2-yl]amino}-9-isopropyl-9H-purin-6-yl)amino]benzoic acid
• Purvalanol B
• Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-
• ng 95
• 2-Chloro-4-[(2-{[(2R)-1-hydroxy-3-methyl-2-butanyl]amino}-9-isopropyl-9H-purin-6-yl)amino]benzoic acid