MDH1-IN-1

• 常用名: MDH1-IN-1
• 英文名: MDH1-IN-1
• CAS号: 2143463-31-2
• 分子量: 355.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₅NO₄
• 熔点: N/A
• 闪点: N/A

MDH1-IN-1用途

MDH1-IN-1(化合物5i)是一种有效的MDH1抑制剂,IC50为6.79μM。MDH1-IN-1具有研究癌症疾病的潜力[1]。

MDH1-IN-1名称

• 英文名: MDH1-IN-1

MDH1-IN-1生物活性

• 描述: MDH1-IN-1(化合物5i)是一种有效的MDH1抑制剂,IC50为6.79μM。MDH1-IN-1具有研究癌症疾病的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Naik R, et al. Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. J Med Chem. 2017;60(20):8631-8646.

MDH1-IN-1物理化学性质

• 分子式: C₂₁H₂₅NO₄
• 分子量: 355.43
• InChIKey: HDBDOZJTIIABKV-UHFFFAOYSA-N
• SMILES: CCCCCc1ccc(OCC(=O)Nc2cccc(C(=O)OC)c2)cc1

MDH1-IN-1靶点实验

查看更多实验

实验名称：Cytotoxicity against human HCT116 cells harboring HRE-Luc assessed as reduction in ce... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4031686

实验名称：Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as t... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4031680

实验名称：Inhibition of MDH2 in human HCT116 cells assessed as increase in intracellular oxygen... 来源：ChEMBL 靶标：Malate dehydrogenase, mitochondrial External Id：CHEMBL4031662

实验名称：Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-... 来源：ChEMBL 靶标：Malate dehydrogenase, cytoplasmic External Id：CHEMBL4031659

实验名称：Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assay 来源：ChEMBL 靶标：Malate dehydrogenase, mitochondrial External Id：CHEMBL4031660

实验名称：Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as t... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4031658

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