PD 174265

• 常用名: PD 174265
• 英文名: PD 174265
• CAS号: 216163-53-0
• 分子量: 371.23100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅BrN₄O
• 熔点: N/A
• 闪点: N/A

PD 174265用途

PD 174265是一种高效、细胞通透性强、可逆和选择性的EGFR抑制剂,IC50为450μm【1】。

PD 174265名称

• 英文名: 4-N-(3-bromophenyl)-6-N-but-1-en-2-ylquinazoline-4,6-diamine

PD 174265生物活性

• 描述: PD 174265是一种高效、细胞通透性强、可逆和选择性的EGFR抑制剂,IC50为450μm【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 参考文献:

  [1]. Fry DW, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.

PD 174265物理化学性质

• 分子式: C₁₇H₁₅BrN₄O
• 分子量: 371.23100
• 精确质量: 370.04300
• PSA: 66.91000
• LogP: 4.63040
• InChIKey: WUPUZEMRHDROEO-UHFFFAOYSA-N
• SMILES: CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
• 储存条件: -20°C，密闭，干燥

PD 174265靶点实验

查看更多实验

实验名称：Kinetics Assay for IC50 Determination from Article 10.1021/jm9002928: "Hybrid compoun... 来源：BindingDB 靶标：N/A External Id：BindingDB_3360_1

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

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