AMP脱氧野尻霉素乙醇溶液

• 常用名: AMP脱氧野尻霉素乙醇溶液
• 英文名: N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
• CAS号: 216758-20-2
• 分子量: 397.549
• 密度: 1.2±0.1 g/cm3
• 沸点: 569.9±50.0 °C at 760 mmHg
• 分子式: C₂₂H₃₉NO₅
• 熔点: N/A
• 闪点: 298.4±30.1 °C

AMP脱氧野尻霉素乙醇溶液用途

AMP脱氧野尻霉素(AMP-DNM)是一种有效的神经酰胺葡萄糖基转移酶和GCase 2抑制剂。AMP脱氧野尻霉素也是一种GlcCr生物合成抑制剂[1][2]。

AMP脱氧野尻霉素乙醇溶液名称

• 中文名: AMP脱氧野尻霉素乙醇溶液
• 英文名: AMP-Deoxynojirimycin

AMP脱氧野尻霉素乙醇溶液生物活性

• 描述: AMP脱氧野尻霉素(AMP-DNM)是一种有效的神经酰胺葡萄糖基转移酶和GCase 2抑制剂。AMP脱氧野尻霉素也是一种GlcCr生物合成抑制剂[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
• 体外研究: AMP脱氧野尻霉素(10μM)显著阻断3T3-L1细胞中亮氨酸和C17ISO诱导的P70S6K磷酸化[1]。
• 参考文献:

  [1]. Zhu M, et al. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Dev Cell. 2021 Oct 11;56(19):2692-2702.e5.

  [2]. Bae EJ, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med. 2015 Mar 27;47(3):e153.

AMP脱氧野尻霉素乙醇溶液物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 569.9±50.0 °C at 760 mmHg
• 分子式: C₂₂H₃₉NO₅
• 分子量: 397.549
• 闪点: 298.4±30.1 °C
• 精确质量: 397.282837
• PSA: 93.39000
• LogP: 3.04
• InChIKey: XVYLNHVEAOOEGI-FAIWKWDXSA-N
• SMILES: OCC1C(O)C(O)C(O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.570
• 储存条件: -20°C，密闭，干燥

AMP脱氧野尻霉素乙醇溶液靶点实验

查看更多实验

实验名称：Inhibition of lactase in mouse intestinal input by glucose release assay 来源：ChEMBL 靶标：Beta-galactosidase External Id：CHEMBL1656921

实验名称：Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as insulin ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1102427

实验名称：Inhibition of maltase in mouse intestinal input by glucose release assay 来源：ChEMBL 靶标：Lysosomal alpha-glucosidase External Id：CHEMBL1656922

实验名称：Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as increase... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1102426

实验名称：Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide sy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1656923

实验名称：Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reductio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1102256

实验名称：Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate pr... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL4395491

实验名称：Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reductio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1102255

实验名称：Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluoroge... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL4395492

实验名称：Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate p... 来源：ChEMBL 靶标：Non-lysosomal glucosylceramidase External Id：CHEMBL4395493

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AMP脱氧野尻霉素乙醇溶液英文别名

• (2R,3R,4R,5S)-1-{5-[(3s,5s,7s)-Adamantan-1-ylmethoxy]pentyl}-2-(hydroxymethyl)-3,4,5-piperidinetriol
• (2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)pentyl]-2-(hydroxymethyl)-3,4,5-piperidinetriol