BMS-986278

• 常用名: BMS-986278
• 英文名: BMS-986278
• CAS号: 2170126-74-4
• 分子量: 445.51
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₁N₅O₅
• 熔点: N/A
• 闪点: N/A

BMS-986278用途

BMS-986278是一种有效的溶血磷脂酸受体1(LPA1)拮抗剂,人LPA1 Kb为6.9 nM。

BMS-986278名称

• 英文名: BMS-986278

BMS-986278生物活性

• 描述: BMS-986278是一种有效的溶血磷脂酸受体1(LPA1)拮抗剂,人LPA1 Kb为6.9 nM。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
• 参考文献:

  [1]. Cheng PTW, et al. Murphy BJ. Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases. J Med Chem. 2021 Nov 11;64(21):15549-15581.

BMS-986278物理化学性质

• 分子式: C₂₂H₃₁N₅O₅
• 分子量: 445.51
• 储存条件: 2-8°C

BMS-986278靶点实验

查看更多实验

实验名称：Hepatobiliary toxicity in Cynomolgus monkey assessed as bile duct hyperplasia at up t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035922

实验名称：Anti-fibrotic activity in Sprague-Dawley rat model of bleomycin-induced lung fibrosis... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5035919

实验名称：Drug metabolism in rat hepatocytes assessed as N-demethylation metabolite formation a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035925

实验名称：Drug metabolism in monkey hepatocytes assessed as N-demethylation metabolite formatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035924

实验名称：Drug metabolism in human hepatocytes assessed as N-demethylation metabolite formation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035923

实验名称：Oral bioavailability in CD-1 mouse at 3 mg/kg measured up to 24 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035850

实验名称：Volume of distribution at steady state in CD-1 mouse at 3 mg/kg, po or 1 mg/kg, iv me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035849

实验名称：Plasma clearance in Cynomolgus monkey at 3 mg/kg, po or 1 mg/kg, iv measured up to 24... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035848

实验名称：Oral bioavailability in cynomolgus monkey at 3 mg/kg measured up to 24 hrs by LC-MS/M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035854

实验名称：Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured up to 24 hrs by LC-MS/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035853

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