Diprovocim

• 常用名: Diprovocim
• 英文名: Diprovocim
• CAS号: 2170867-89-5
• 分子量: 909.1
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₆H₅₆N₆O₆
• 熔点: N/A
• 闪点: N/A

Diprovocim用途

Diprovocim是一种有效的Toll样受体TLR1/TLR2激动剂,可诱导剂量依赖性TNF产生,人THP-1细胞EC50为110 pM,原代小鼠腹腔巨噬细胞EC50为1.3 nM；诱导骨髓来源的TNF产生EC50为6.7 nM的树突状细胞(BMDC)也诱导小鼠BMDC产生IL-6；诱导IKKα,IKKβ,p38,JNK和ERK的磷酸化,以及THP-1细胞和小鼠腹膜巨噬细胞中IκBα的降解,激活常规TLR1/TLR2信号传导,包括MAPK和经典NF-κB信号传导；与抗协同作用PD-L1消除小鼠黑色素瘤。

Diprovocim名称

• 英文名: Diprovocim

Diprovocim生物活性

• 描述: Diprovocim是一种有效的Toll样受体TLR1/TLR2激动剂,可诱导剂量依赖性TNF产生,人THP-1细胞EC50为110 pM,原代小鼠腹腔巨噬细胞EC50为1.3 nM；诱导骨髓来源的TNF产生EC50为6.7 nM的树突状细胞(BMDC)也诱导小鼠BMDC产生IL-6；诱导IKKα,IKKβ,p38,JNK和ERK的磷酸化,以及THP-1细胞和小鼠腹膜巨噬细胞中IκBα的降解,激活常规TLR1/TLR2信号传导,包括MAPK和经典NF-κB信号传导；与抗协同作用PD-L1消除小鼠黑色素瘤。
• 参考文献: References 1. Wang Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201809232. View Related Products by Target Toll-like Receptor (TLR)

Diprovocim物理化学性质

• 分子式: C₅₆H₅₆N₆O₆
• 分子量: 909.1

Diprovocim靶点实验

查看更多实验

实验名称：Immuno-adjuvant activity in C57BL/6J mouse assessed as increase in level of OVA speci... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5149154

实验名称：Immuno-adjuvant activity in C57BL/6J mouse assessed as increase in level of OVA speci... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5149155

实验名称：Agonist activity at TLR1/TLR2 in wild type C57BL/6J mouse macrophages assessed as sti... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5149150

实验名称：Agonist activity at TLR1/TLR2 in wild type C57BL/6J mouse macrophages assessed as sti... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5149151

实验名称：In vivo cytotoxicity against C57BL/6 mouse-derived splenocytes loaded with SIINFEKL p... 来源：ChEMBL 靶标：Splenocyte External Id：CHEMBL5149152

实验名称：Immuno-adjuvant activity in C57BL/6J mouse assessed as increase in level of OVA speci... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5149153

实验名称：Agonist activity at human TLR1/TLR2 Y332A mutant expressed in HEK293T cells coexpress... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4392922

实验名称：Agonist activity at human TLR1/TLR2 L350A mutant expressed in HEK293T cells coexpress... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4392923

实验名称：Agonist activity at human TLR1/TLR2 Y376 mutant expressed in HEK293T cells coexpressi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4392924

实验名称：Agonist activity at TLR1/TLR2 in human THP-1 derived macrophages assessed as stimulat... 来源：ChEMBL 靶标：Toll-like receptor 1 External Id：CHEMBL5149148

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