Diprovocim
Modify Date: 2024-01-11 21:50:54
Diprovocim structure
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Common Name | Diprovocim | ||
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| CAS Number | 2170867-89-5 | Molecular Weight | 909.1 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C56H56N6O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DiprovocimDiprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages; induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC; induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice. |
| Name | Diprovocim |
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| Description | Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages; induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC; induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice. |
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| References | References 1. Wang Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201809232. View Related Products by Target Toll-like Receptor (TLR) |
| Molecular Formula | C56H56N6O6 |
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| Molecular Weight | 909.1 |