半齿泽兰素-5-甲醚

• 常用名: 半齿泽兰素-5-甲醚
• 英文名: Eupatorin-5-methylether
• CAS号: 21764-09-0
• 分子量: 358.34200
• 密度: 1.309g/cm3
• 沸点: 573.7ºC at 760mmHg
• 分子式: C₁₉H₁₈O₇
• 熔点: 179-180ºC
• 闪点: 207.4ºC

半齿泽兰素-5-甲醚用途

Eupatorin-5-methyl ether (TMF) 可以从 Orthosiphon stamineus 中分离得到。Eupatorin-5-methyl ether 是一种黄酮类化合物。 Eupatorin-5-methyl ether 抑制 NO 产生 (IC50 5.5 μM)。

半齿泽兰素-5-甲醚名称

• 中文名: 半齿泽兰素-5-甲醚
• 英文名: 2-(3-hydroxy-4-methoxyphenyl)-5,6,7-trimethoxychromen-4-one
• 中文别名: 3-羟基-4,5,6,7-四甲氧基黄酮

半齿泽兰素-5-甲醚生物活性

• 描述: Eupatorin-5-methyl ether (TMF) 可以从 Orthosiphon stamineus 中分离得到。Eupatorin-5-methyl ether 是一种黄酮类化合物。 Eupatorin-5-methyl ether 抑制 NO 产生 (IC50 5.5 μM)。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Mirka Laavola, et al. Flavonoids Eupatorin and Sinensetin Present in Orthosiphon stamineus Leaves Inhibit Inflammatory Gene Expression and STAT1 Activation. Planta Med. 2012, 78, 08.

半齿泽兰素-5-甲醚物理化学性质

• 密度: 1.309g/cm3
• 沸点: 573.7ºC at 760mmHg
• 熔点: 179-180ºC
• 分子式: C₁₉H₁₈O₇
• 分子量: 358.34200
• 闪点: 207.4ºC
• 精确质量: 358.10500
• PSA: 87.36000
• LogP: 3.20000
• InChIKey: LYLDPYNWDVVPIQ-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1O
• 蒸汽压: 9.21E-14mmHg at 25°C
• 折射率: 1.593

半齿泽兰素-5-甲醚安全信息

• 危害码 (欧洲): T
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 海关编码: 2914509090

半齿泽兰素-5-甲醚海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

半齿泽兰素-5-甲醚靶点实验

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实验名称：Anticancer activity against non-CYP1 expressing human MCF10A cells by MTT assay 来源：ChEMBL 靶标：MCF-10A External Id：CHEMBL1780348

实验名称：Antiproliferative effect against human colonic cell line (HT-29) after 24 hr at a con... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL837838

实验名称：Activity at CYP1A1 in microsomes of human MDA-MB468 cells assessed as parent compound... 来源：ChEMBL 靶标：Cytochrome P450 1A1 External Id：CHEMBL1780385

实验名称：Activation factor, ratio of IC50 for non-CYP1 expressing human MCF10A to IC50 for CYP... 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL1780384

实验名称：Activity at recombinant CYP1B1 assessed as E5M1 metabolite elution time at 10 uM by H... 来源：ChEMBL 靶标：Cytochrome P450 1A1 External Id：CHEMBL1780387

实验名称：Activity at recombinant CYP1A1 assessed as E5M1 metabolite elution time at 10 uM by H... 来源：ChEMBL 靶标：Cytochrome P450 1A1 External Id：CHEMBL1780386

实验名称：Inhibition of procoagulant activity in monocyte from human blood assessed as countera... 来源：ChEMBL 靶标：Monocyte External Id：CHEMBL1027643

实验名称：Antiproliferative effect against human colonic cell line (HT-29) after 6 hr at a conc... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL837167

实验名称：Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxy... 来源：ChEMBL 靶标：Cytochrome P450 1A1 External Id：CHEMBL1780345

实验名称：Anticancer activity against CYP1 expressing human MDA-MB-468 cells by MTT assay 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL1780347

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半齿泽兰素-5-甲醚英文别名

• Eupatorin 5-Methyl Ether
• 3'-hydroxy-4',5,6,7-tetramethoxyflavone
• 2-(3,4dihydroxyphenyl)-5-hydroxy-7-[3,4,5-trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6 tetrahydropyran-2-yloxy)]chromen-4-one
• 5-OMe-eupatorin
• 3'-hydroxy-5,6,7,4'-tetramethoxyflavone