3,4'-二羟基-3'-甲氧基苯丙酮

• 常用名: 3,4'-二羟基-3'-甲氧基苯丙酮
• 英文名: Propiophenone, 3,4'-dihydroxy-3'-methoxy
• CAS号: 2196-18-1
• 分子量: 196.200
• 密度: 1.2±0.1 g/cm3
• 沸点: 408.2±35.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂O₄
• 熔点: N/A
• 闪点: 165.4±19.4 °C

3,4'-二羟基-3'-甲氧基苯丙酮用途

天然化合物β-羟基丙泊酚酮对α-葡萄糖苷酶具有显著的浓度依赖性抑制作用,IC50为257.8μg/mL[1]。

3,4'-二羟基-3'-甲氧基苯丙酮名称

• 中文名: 3,4'-二羟基-3'-甲氧基苯丙酮
• 英文名: 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one

3,4'-二羟基-3'-甲氧基苯丙酮生物活性

• 描述: 天然化合物β-羟基丙泊酚酮对α-葡萄糖苷酶具有显著的浓度依赖性抑制作用,IC50为257.8μg/mL[1]。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点实验:

  IC50: 257.8 μg/mL (α-glucosidase)[1]

• 体外研究: 通过使用2,3-二氯-5,6-二氰基-1,4-苯醌/亚硝酸叔丁酯/O2对木质素进行化学选择性催化氧化,然后用锌裂解芳基甘油-β-芳基醚,可获得β-羟基丙泊酚酮及其类似物[2]。在SYK-6细胞中,β-羟基丙泊酚酮(HPV)通过香草基乙醛(VAL)氧化为香草基乙酸(VAA)。产生的VAA通过辅酶A激活VAA进一步转化为钒酸盐[3]。
• 参考文献:

  [1]. Lv Q , et al. Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro. Food Funct. 2019;10(5):2881-2887.

  [2]. Higuchi Y, et al. Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin. Appl Environ Microbiol. 2018;84(7):e02670-17. Published 2018 Mar 19.

  [3]. Higuchi Y, et al. Discovery of novel enzyme genes involved in the conversion of an arylglycerol-β-aryl ether metabolite and their use in generating a metabolic pathway for lignin valorization. Metab Eng. 2019;55:258-267.

3,4'-二羟基-3'-甲氧基苯丙酮物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 408.2±35.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂O₄
• 分子量: 196.200
• 闪点: 165.4±19.4 °C
• 精确质量: 196.073563
• PSA: 66.76000
• LogP: 0.69
• InChIKey: NXCPMSUBVRGTSE-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)CCO)ccc1O
• 外观性状: 晶体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.561
• 储存条件: 2-8℃，干燥，密闭

3,4'-二羟基-3'-甲氧基苯丙酮安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

3,4'-二羟基-3'-甲氧基苯丙酮海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

3,4'-二羟基-3'-甲氧基苯丙酮靶点实验

查看更多实验

实验名称：Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1068155

实验名称：Anticancer activity against human SKOV3 cells by SRB assay 来源：ChEMBL 靶标：SK-OV-3 External Id：CHEMBL1763717

实验名称：Anticancer activity against human SK-MEL-2 cells by SRB assay 来源：ChEMBL 靶标：SK-MEL-2 External Id：CHEMBL1763719

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3404170

实验名称：Anticancer activity against human A549 cells by SRB assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL1763718

实验名称：Anticancer activity against human XF498 cells by SRB assay 来源：ChEMBL 靶标：XF498 External Id：CHEMBL1763720

实验名称：Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1068146

共7条，当前第1页，共1页

1

3,4'-二羟基-3'-甲氧基苯丙酮英文别名

• Propiophenone,3,4'-dihydroxy-3'-methoxy
• 3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone