TH34

• 常用名: TH34
• 英文名: TH34
• CAS号: 2196203-96-8
• 分子量: 256.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₆N₂O₂
• 熔点: N/A
• 闪点: N/A

TH34用途

TH34 是一种 HDAC6/8/10 抑制剂,IC50 值分别为 4.6 μM、1.9 μM、7.7 μM,与 HDAC1/2/3 相比,显示出高选择性。

TH34名称

• 中文名: TH34
• 英文名: TH34

TH34生物活性

• 描述: TH34 是一种 HDAC6/8/10 抑制剂,IC50 值分别为 4.6 μM、1.9 μM、7.7 μM,与 HDAC1/2/3 相比,显示出高选择性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  HDAC6:4.6 μM (IC50)

  HDAC8:1.9 μM (IC50)

  HDAC10:7.7 μM (IC50)

• 体外研究: TH34在神经母细胞瘤细胞中诱导caspase依赖的程序性细胞死亡和细胞周期停滞[1]。
• 参考文献:

  [1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.

TH34物理化学性质

• 分子式: C₁₅H₁₆N₂O₂
• 分子量: 256.30
• 储存条件: 2-8℃

TH34靶点实验

查看更多实验

实验名称：Cytotoxicity against HEK293 cells assessed as cell viability at 50 uM after 24 hrs by... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4027162

实验名称：Inhibition of HDAC6 in human BE(2)-C cells assessed as induction of increase in alpha... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4027160

实验名称：Inhibition of HDAC8 in human BE(2)-C cells assessed as induction of increase in SMC3 ... 来源：ChEMBL 靶标：Histone deacetylase 8 External Id：CHEMBL4027161

实验名称：NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C... 来源：NCGC 靶标：N/A External Id：adst_HEK293_Anti-infectives-02

实验名称：Cytotoxicity against human BE(2)-C cells assessed as reduction in clonogenic growth a... 来源：ChEMBL 靶标：BE(2)-C External Id：CHEMBL4027158

实验名称：NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay 来源：NCGC 靶标：N/A External Id：adst_Celegans_Anti-infectives-o1

实验名称：Inhibition of HDAC1 in human BE(2)-C cells assessed as effect on histone H3 acetylati... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL4027159

实验名称：Selectivity index, ratio of IC50 for recombinant human full length C-terminal FLAG-ta... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4027170

实验名称：Selectivity index, ratio of IC50 for recombinant human full length HDAC6 to IC50 for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4027165

实验名称：Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC1 expressed in... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL4027176

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