UKI-1

• 常用名: UKI-1
• 英文名: UKI-1
• CAS号: 220355-63-5
• 分子量: 613.811
• 密度: 1.2±0.1 g/cm3
• 沸点: 745.5±70.0 °C at 760 mmHg
• 分子式: C₃₂H₄₇N₅O₅S
• 熔点: N/A
• 闪点: 404.6±35.7 °C

UKI-1用途

UKI-1是尿激酶型纤溶酶原激活剂(u-PA)抑制剂,也能够抑制癌细胞的侵袭能力。

UKI-1名称

• 中文名: UKI-1
• 英文名: UKI-1

UKI-1生物活性

• 描述: UKI-1是尿激酶型纤溶酶原激活剂(u-PA)抑制剂,也能够抑制癌细胞的侵袭能力。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 感染
• 参考文献:

  [1]. Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24.

  [2]. Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.

UKI-1物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 745.5±70.0 °C at 760 mmHg
• 分子式: C₃₂H₄₇N₅O₅S
• 分子量: 613.811
• 闪点: 404.6±35.7 °C
• 精确质量: 613.329773
• LogP: 6.36
• InChIKey: ISJSHQTWOHGCMM-NDEPHWFRSA-N
• SMILES: CCOC(=O)N1CCN(C(=O)C(Cc2cccc(C(=N)N)c2)NS(=O)(=O)c2c(C(C)C)cc(C(C)C)cc2C(C)C)CC1
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.595
• 储存条件: 2-8℃

UKI-1靶点实验

查看更多实验

实验名称：Inhibition of matriptase 来源：ChEMBL 靶标：Suppressor of tumorigenicity 14 protein External Id：CHEMBL868541

实验名称：Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate prein... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL1947445

实验名称：Inhibition of uPA 来源：ChEMBL 靶标：Urokinase-type plasminogen activator External Id：CHEMBL868542

实验名称：Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubate... 来源：ChEMBL 靶标：Tissue-type plasminogen activator External Id：CHEMBL1947444

实验名称：Inhibition of plasmin 来源：ChEMBL 靶标：Plasminogen External Id：CHEMBL868543

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Inhibition of thrombin 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL868544

实验名称：Selectivity ratio of Ki for recombinant tPA to Ki for human uPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL1947449

实验名称：ASTRAZENECA: Solubility in pH7.4 buffer using solid starting material using the metho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301364

实验名称：Inhibition of uPA 来源：ChEMBL 靶标：Urokinase-type plasminogen activator External Id：CHEMBL927669

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UKI-1英文别名

• 1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester
• Ethyl 4-{3-carbamimidoyl-N-[(2,4,6-triisopropylphenyl)sulfonyl]-L-phenylalanyl}-1-piperazinecarboxylate
• ethyl 4-(3-carbamimidoyl-N-{[2,4,6-tri(propan-2-yl)phenyl]sulfonyl}-L-phenylalanyl)piperazine-1-carboxylate