罗美昔布

• 常用名: 罗美昔布
• 英文名: Lumiracoxib
• CAS号: 220991-20-8
• 分子量: 293.721
• 密度: 1.4±0.1 g/cm3
• 沸点: 395.7±42.0 °C at 760 mmHg
• 分子式: C₁₅H₁₃ClFNO₂
• 熔点: 139-141ºC
• 闪点: 193.1±27.9 °C

罗美昔布用途

Lumiracoxib, also known as CGS 35189 and COX 189, is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug, manufactured by Novartis and still sold in few countries, including Mexico, Ecuador and the Dominican Republic, under the trade name Prexige. Since its original approval, lumiracoxib has been withdrawn from the market in several countries, mostly due to its potential for causing liver failure (sometimes requiring liver transplantation). It has never been approved for use in the United States.

罗美昔布名称

• 中文名: 罗美昔布
• 英文名: lumiracoxib
• 中文别名: 2-[(2-氯-6-氟苯基)氨基」-5-甲基苯乙酸 | 鲁米昔布

罗美昔布物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 395.7±42.0 °C at 760 mmHg
• 熔点: 139-141ºC
• 分子式: C₁₅H₁₃ClFNO₂
• 分子量: 293.721
• 闪点: 193.1±27.9 °C
• 精确质量: 293.061890
• PSA: 49.33000
• LogP: 3.90
• InChIKey: KHPKQFYUPIUARC-UHFFFAOYSA-N
• SMILES: Cc1ccc(Nc2c(F)cccc2Cl)c(CC(=O)O)c1
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.628
• 储存条件: -20°C Freezer

罗美昔布靶点实验

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实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 green ... 来源：NCGC 靶标：N/A External Id：Ebola screen2_EMI141217_green

实验名称：qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 ratio ... 来源：NCGC 靶标：N/A External Id：Ebola screen2_EMI141217_ratio

实验名称：qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 blue c... 来源：NCGC 靶标：N/A External Id：Ebola screen2_EMI141217_blue

实验名称：qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen 2, green... 来源：NCGC 靶标：N/A External Id：Ebola screen2_EM141217_green

实验名称：insulin secretion from INS-1E cells in the presence of 5 mM glucose-screen 来源：846 靶标：N/A External Id：5mMGluc_INS1E_InsulinRelease_40mMGluc_SP

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 External Id：ERR985

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罗美昔布英文别名

• 2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzeneacetic acid
• Prexige (Novartis)
• 2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid
• {2-[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
• Prexige
• COX189
• 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid
• Joicela
• (2-((2-chloro-6-fluorophenyl)-amino)-5-methylphenyl)-acetic acid
• Lumiracoxib
• [14C]-Lumiracoxib
• 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
• Lumiracoxib [USAN:INN]