4-氨基-1-叔丁基-3-(1’-萘)吡唑并[3,4-d]嘧啶

• 常用名: 4-氨基-1-叔丁基-3-(1’-萘)吡唑并[3,4-d]嘧啶
• 英文名: 1-Naphthyl PP1
• CAS号: 221243-82-9
• 分子量: 317.388
• 密度: 1.3±0.1 g/cm3
• 沸点: 527.8±45.0 °C at 760 mmHg
• 分子式: C₁₉H₁₉N₅
• 熔点: 219-222ºC
• 闪点: 273.0±28.7 °C

用途

1-Naphthyl PP1(1-NA-PP 1)是src家族抑制剂,对v-Src,c-Fyn,c-Abl,CDK2和CAMK II的IC50分别为1.0,0.6,0.6,18和22 _mu_M。

名称

• 中文名: 4-氨基-1-叔丁基-3-(1’-萘)吡唑并[3,4-d]嘧啶
• 英文名: 1-na-pp1
• 中文别名: 1-PP1萘 | 4-氨基-1-叔丁基-3-(1`-萘)吡唑并[3,4-d]嘧啶 | 4-氨基-1-叔丁基-3-(1'-萘基)吡唑并[3,4-D]嘧啶

生物活性

• 描述: 1-Naphthyl PP1(1-NA-PP 1)是src家族抑制剂,对v-Src,c-Fyn,c-Abl,CDK2和CAMK II的IC50分别为1.0,0.6,0.6,18和22 _mu_M。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> SRC
  研究领域 >> 癌症
• 参考文献:

  [1]. Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401.

  [2]. Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 527.8±45.0 °C at 760 mmHg
• 熔点: 219-222ºC
• 分子式: C₁₉H₁₉N₅
• 分子量: 317.388
• 闪点: 273.0±28.7 °C
• 精确质量: 317.164032
• PSA: 69.62000
• LogP: 3.88
• InChIKey: XSHQBIXMLULFEV-UHFFFAOYSA-N
• SMILES: CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21
• 外观性状: 白色水晶般的固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.688
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Inhibition of PKD1 (unknown origin) 来源：ChEMBL 靶标：Serine/threonine-protein kinase D1 External Id：CHEMBL5316849

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5550260

实验名称：Luminescent Kinase Assay from US Patent US11247972: "Compositions and methods for tre... 来源：BindingDB 靶标：N/A External Id：BindingDB_10458_2

实验名称：KinaseGlo Assay from US Patent US11247972: "Compositions and methods for treating tox... 来源：BindingDB 靶标：N/A External Id：BindingDB_10458_1

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

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英文别名

• 1-(2-Methyl-2-propanyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• 1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine
• 4-Amino-1-tert-butyl-3-(1,-naphthyl)pyrazolo[3,4-d]pyrimidine
• 1-NA-PP1
• 1-tert-butyl-3-(1-naphthyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine
• 1-Naphthyl PP1