佐他莫司(ABT-578)

• 常用名: 佐他莫司(ABT-578)
• 英文名: Zotarolimus
• CAS号: 221877-54-9
• 分子量: 966.210
• 密度: 1.3±0.1 g/cm3
• 沸点: 1016.2±75.0 °C at 760 mmHg
• 分子式: C₅₂H₇₉N₅O₁₂
• 熔点: 100-105°C
• 闪点: 568.4±37.1 °C

佐他莫司(ABT-578)用途

Zotarolimus 是雷帕霉素类似物。

佐他莫司(ABT-578)名称

• 中文名: 唑他莫司
• 英文名: Zotarolimus
• 中文别名: 佐他莫司 | 他莫司

佐他莫司(ABT-578)生物活性

• 描述: Zotarolimus 是雷帕霉素类似物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Wagner R et al. Rapamycin analogs with reduced systemic exposure. et al. Bioorg Med Chem Lett. 2005 Dec 1, 15(23), 5340-3.

佐他莫司(ABT-578)物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 1016.2±75.0 °C at 760 mmHg
• 熔点: 100-105°C
• 分子式: C₅₂H₇₉N₅O₁₂
• 分子量: 966.210
• 闪点: 568.4±37.1 °C
• 精确质量: 965.572510
• PSA: 218.80000
• LogP: 3.55
• InChIKey: CGTADGCBEXYWNE-VNODUHINSA-N
• SMILES: COC1CC2CCC(C)C(O)(O2)C(=O)C(=O)N2CCCCC2C(=O)OC(C(C)CC2CCC(n3cnnn3)C(OC)C2)CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C1C
• 外观性状: 粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.586
• 储存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

佐他莫司(ABT-578)安全信息

• 海关编码: 29349990

佐他莫司(ABT-578)靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Human FK506 binding protein 1A (5.2.-.- Cis-trans-isomerases) 来源：IUPHAR-DB 靶标：FK506 binding protein 1A (5.2.-.- Cis-trans-isomerases) [Homo sapiens] External Id：2609_Human

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Apparent terminal half life in Sprague-Dawley rat at 2.5 mg/kg, po administered via g... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4258272

实验名称：Apparent terminal half life in Sprague-Dawley rat at 2.5 mg/kg, iv administered as bo... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4258271

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5550262

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佐他莫司(ABT-578)英文别名

• (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-19,30-dimethoxy-12-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-2-propanyl}-15,17,21,23,29,35-hexamethyl-11, ;36-dioxa-4-azatricyclo[30.3.1.0]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-3-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]propan-2-yl}-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• Zotarolimus
• ABT-578