ZL0590

• 常用名: ZL0590
• 英文名: ZL0590
• CAS号: 2230496-99-6
• 分子量: 512.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₇F₃N₄O₄S
• 熔点: N/A
• 闪点: N/A

ZL0590用途

ZL0590是一种有效的口服活性BRD4 BD1选择性抑制剂,对人BRD4 BD1的IC50为90 nM。ZL0590具有显著的抗炎活性[1]。

ZL0590名称

• 英文名: ZL0590

ZL0590生物活性

• 描述: ZL0590是一种有效的口服活性BRD4 BD1选择性抑制剂,对人BRD4 BD1的IC50为90 nM。ZL0590具有显著的抗炎活性[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  IC50: 90 nM (human BRD4 BD1)[1]

• 参考文献:

  [1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408.

ZL0590物理化学性质

• 分子式: C₂₃H₂₇F₃N₄O₄S
• 分子量: 512.55
• InChIKey: ZPMULUKHFNMJPF-FQEVSTJZSA-N
• SMILES: O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)N2CCCC2CN2CCOCC2)cc1

ZL0590靶点实验

查看更多实验

实验名称：Binding affinity to wild type human BRD4 BD1 (42 to168 residues) expressed in bacteri... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5044426

实验名称：Antiinflammatory activity in human SAEC assessed as inhibition of Poly(I:C) induced I... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044423

实验名称：Binding affinity to wild type human BRD4 BD1 (44 to 168 residues) assessed as change ... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5044418

实验名称：Binding affinity to wild type human BRD4 BD1 (44 to 168 residues) assessed as change ... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5044417

实验名称：Binding affinity to wild type human BRD4 BD1 (44 to 168 residues) assessed as change ... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5044416

实验名称：Antiinflammatory activity in human SAEC assessed as inhibition of Poly(I:C) induced C... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044422

实验名称：AUC (0 to t) in rat at 20 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044421

实验名称：Binding affinity to wild type human BRD4 BD2 (349 to 461 residues) assessed as change... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5044419

实验名称：Volume of distribution at steady state in rat at 20 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044458

实验名称：AUC (0 to t) in rat at 10 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044457

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