查杷任酮

• 常用名: 查杷任酮
• 英文名: Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)- (9CI)
• CAS号: 22611-34-3
• 分子量: 378.42
• 密度: 1.45g/cm3
• 沸点: 626.1ºC at 760mmHg
• 分子式: C₂₀H₂₆O₇
• 熔点: N/A
• 闪点: 224.9ºC

查杷任酮用途

Chaparrinone 是一种苦木素类化合物,可以从 Eurycoma Harmandiana 的根中分离出来。 Chaparrinone 对 Plasmodium falciparum 和 P-388 细胞具有抗疟和细胞毒活性 (IC50 分别为 0.037 和 0.34 μg/mL)。

查杷任酮名称

• 中文名: 查杷任酮
• 英文名: chaparrinone

查杷任酮生物活性

• 描述: Chaparrinone 是一种苦木素类化合物,可以从 Eurycoma Harmandiana 的根中分离出来。 Chaparrinone 对 Plasmodium falciparum 和 P-388 细胞具有抗疟和细胞毒活性 (IC50 分别为 0.037 和 0.34 μg/mL)。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8.

  [2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40.

查杷任酮物理化学性质

• 密度: 1.45g/cm3
• 沸点: 626.1ºC at 760mmHg
• 分子式: C₂₀H₂₆O₇
• 分子量: 378.42
• 闪点: 224.9ºC
• 精确质量: 378.16800
• PSA: 113.29000
• LogP: 0.16620
• InChIKey: VLYMLZRDCSQUQF-RZUZYEBMSA-N
• SMILES: CC1=CC(=O)C(O)C2(C)C1CC1OC(=O)CC3C(C)C(O)C4(O)OCC13C42
• 蒸汽压: 2.67E-18mmHg at 25°C
• 折射率: 1.627

查杷任酮毒性和生态

查杷任酮靶点实验

查看更多实验

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Cytotoxicity against mouse P388 cells after 3 days by MTT assay 来源：ChEMBL 靶标：P388 External Id：CHEMBL1014171

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 at 5 ug after 48 hrs by si... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1019083

实验名称：Antibacterial activity against Bacillus subtilis ATCC 6633 at 5 ug after 48 hrs by si... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL1019082

实验名称：Induction of cell differentiation in human HL60 cells assessed as superoxide anion pr... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL937974

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

实验名称：Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thy... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL937973

实验名称：Selectivity index, ratio of cytotoxic IC50 to antiproliferative IC50 for human HL60 c... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL937976

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL3436042

实验名称：Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 ... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL937975

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查杷任酮英文别名

• Chaparvinon