S1P2 antagonist 1

• 常用名: S1P2 antagonist 1
• 英文名: S1P2 antagonist 1
• CAS号: 2262402-83-3
• 分子量: 452.89
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁ClN₄O₄
• 熔点: N/A
• 闪点: N/A

S1P2 antagonist 1用途

S1P2拮抗剂1是一种口服生物利用的S1P2拮抗剂,用于治疗纤维性疾病。

S1P2 antagonist 1名称

• 英文名: S1P2 antagonist 1

S1P2 antagonist 1生物活性

• 描述: S1P2拮抗剂1是一种口服生物利用的S1P2拮抗剂,用于治疗纤维性疾病。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
• 参考文献:

  [1]. Mammoliti O, et al. Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases. J Med Chem. 2021 Oct 14;64(19):14557-14586.

S1P2 antagonist 1物理化学性质

• 分子式: C₂₃H₂₁ClN₄O₄
• 分子量: 452.89
• InChIKey: PMFUQAVMFHEJFO-CYBMUJFWSA-N
• SMILES: CC(C(=O)O)n1nc(Cn2cc3cc(OCC4CC4)c(Cl)cc3n2)c2ccccc2c1=O

S1P2 antagonist 1靶点实验

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实验名称：Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-in... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 2 External Id：CHEMBL5046713

实验名称：Unbound intrinsic clearance in mouse liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046712

实验名称：Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibit... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 2 External Id：CHEMBL5046710

实验名称：Unbound intrinsic clearance in human cryopreserved hepatocytes at 1 uM measured up to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046717

实验名称：Unbound intrinsic clearance in human liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046716

实验名称：Antagonist activity at IL8 receptor in HFL1 cells assessed as inhibition of EC80 S1P-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046715

实验名称：Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-in... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 2 External Id：CHEMBL5046714

实验名称：Efflux ratio of apparent permeability across apical to basolateral side in human Caco... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046705

实验名称：Unbound plasma concentration in Sprague-Dawley rat at 1 mg/kg, iv measured after 3 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046704

实验名称：Unbound intrinsic clearance in mouse cryopreserved hepatocytes at 1 uM measured up to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5046703

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